Epigenetics in differentiation of acute promyelocytic leukemia cells by synthetic retinoids

2014 Fiscal Year Final Research Report

• Project/Area Number: 23591558
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Multi-year Fund
• Section: 一般
• Research Field: Pediatrics
• Research Institution: Osaka Medical College
• Principal Investigator: INOUE Akiko 大阪医科大学, 医学部, 講師 (90330076)
• Co-Investigator(Kenkyū-buntansha): TAKITANI Kimitaka 大阪医科大学, 医学部, 講師 (80319540)
• Project Period (FY): 2011-04-28 – 2015-03-31
• Keywords: 急性前骨髄球性白血病 / レチノイド / エピジェネティクス

Outline of Final Research Achievements

Recently, it is reported that the differentiation of acute promyelocytic leukemia (APL) cells by all-trans retinoic acid (ATRA) is related with epigenetics mechanism. In the current study, we examined the epigenetics in differentiation of APL cells by synthetic retinoids. Am80 as synthetic retinoid up-regulated transcriptional activity of RAR and RXR with MLL5 (mixed lineage leukemia 5, short form), which is the key molecule of epigenetics in differentiation of APL cells. Further investigations are required to clarify this issue.

Free Research Field

小児血液腫瘍学