2013 Fiscal Year Final Research Report
Comprehensive genome analysis of aggressive neuroblastoma
| Project/Area Number |
23591562
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Pediatrics
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| Research Institution | Chiba Cancer Center (Research Institute) |
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Principal Investigator |
OHIRA Miki 千葉県がんセンター(研究所), がんゲノム研究室, 室長 (20311384)
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| Co-Investigator(Renkei-kenkyūsha) |
NAKAGAWARA Akira 千葉県がんセンター, 病院長 (50117181)
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| Project Period (FY) |
2011 – 2013
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| Keywords | 癌 / 神経芽腫 / マイクロアレイ / 遺伝子 / ゲノム |
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| Research Abstract |
Neuroblastoma is one of the most common cancer in children, and is known to exhibit wide ranges of clinical behavior, from spontaneous regression to highly resistant to chemotherapy. In this study, to construct better therapeutic strategies for each tumor subtype, we conducted integrated molecular profiling to find genome copy number aberrations, mRNA/miRNA expression patterns as well as epigenetic changes occurred frequently in aggressive neuroblastomas. A set of markers we found showed significant correlations with patient prognoses and could add new insights to develop a novel diagnostic system or to select suitable clinical treatment by using them.
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[Journal Article] NCYM, a cis-antisense gene of MYCN, encodes a de novo evolved protein that inhibits GSK3beta resulting in the stabilization of MYCN in human neuroblastomas2014
Author(s)
Suenaga Y, Islam SM, Alagu J, Kaneko Y, Kato M, Tanaka Y, Kawana H, Hossain S, Matsumoto D, Yamamoto M, Shoji W, Itami M, Shibata T, Nakamura Y, Ohir a M, Haraguchi S, Takatori A, Nakagawara A.
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Journal Title
PLOS Genet
Volume: 10
Pages: e1003996
DOI
Peer Reviewed
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[Journal Article] ALK is a MYCN target gene and regulates cell migration and invasion in neuroblastoma2013
Author(s)
Hasan MK, Nafady A, Takatori A, Kishida S, Ohir a M, Suenaga Y, Hossain S, Akter J, Ogura A, Nakamura Y, Kadomatsu K, Nakagawara A.
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Journal Title
Sci Rep
Volume: 3
Pages: 3450
DOI
Peer Reviewed
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[Journal Article] Dependence receptor UNC5D mediates nerve growth factor depletion-induced neuroblastoma regression2013
Author(s)
Zhu Y, Li Y, Haraguchi S, Yu M, Ohir a M, Ozaki T, Nakagawa A, Ushijima T, Isogai E, Koseki H, Nakamura Y, Kong C, Mehlen P, Arakawa H, Nakagawara A.
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Journal Title
J Clin Invest
Volume: 123
Pages: 2935-2947
Peer Reviewed
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[Journal Article] Temozolomide suppresses MYC via activation of TAp63 to inhibit progression of human glioblastoma2013
Author(s)
Yamaki T, Suenaga Y, Iuchi T, Alagu J, Takatori A, Itami M, Araki A, Ohir a M, Inoue M, Kageyama H, Yokoi S, Saeki N, Nakagawara A.
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Journal Title
Sci Rep
Volume: 3
Pages: 1160
DOI
Peer Reviewed
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[Journal Article] Cell culture and Drosophila model systems define three classes of anaplastic lymphoma kinase mutations in neuroblastoma2013
Author(s)
Chand D, Yamazaki Y, Ruuth K, Schönherr C, Martinsson T, Kogner P, Attiyeh EF, Maris J, Morozova O, Marra MA, Ohira M, Nakagawara A, Sandström PE, Palmer RH, Hallberg B.
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Journal Title
Dis Model and Mech
Volume: 6
Pages: 373-382
Peer Reviewed
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[Journal Article] ALK fusion gene positive lung cancer and 3 cases treated with an inhibitor for ALK kinase activity2012
Author(s)
Kimura H, Nakajima T, Takeuchi K, Soda M, Mano H, Iizasa T, Matsui Y, Yoshino M, Shingyoji M, Itakura M, Itami M, Ikebe D, Yokoi S, Kageyama H, Ohir a M, Nakagawara A.
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Journal Title
Lung Cancer
Volume: 75
Pages: 66-72
Peer Reviewed
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[Journal Article] A novel potent tumour promoter aberrantly overexpressed in most human cancers2011
Author(s)
Takahashi A, Tokita H, Takahashi K, Takeoka T, Murayama K, Tomotsune D, Ohir a M, Iwamatsu A, Ohara K, Yazaki K, Koda T, Nakagawara A, Tani K.
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Journal Title
Sci Rep
Volume: 1
Pages: 15
DOI
Peer Reviewed
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