2013 Fiscal Year Final Research Report
A diagnostic method of focal segmental glomerulosclerosis by low vacuum scanning electron microscopy
| Project/Area Number |
23591568
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Pediatrics
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| Research Institution | Tottori University |
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Principal Investigator |
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| Co-Investigator(Renkei-kenkyūsha) |
INAGA Sumire 鳥取大学, 医学部, 助教 (60116358)
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| Project Period (FY) |
2011 – 2013
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| Keywords | 低真空走査型電子顕微鏡 / ネフローゼ症候群 |
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| Research Abstract |
We observed renal biopsy paraffin sections of nephrotic syndrome (NS) patients by low vacuum scanning electron microscopy (LVSEM). The round-shaped podocyte cell bodies were noted especially in steroid-resistant NS specimens compared with steroid-sensitive NS. The morphological changes of podocytes cell bodies may be related to the decreased expressions of nephrin or podocin in glomeruli. An application of a LVSEM to renal biopsy paraffin sections of NS patients was useful to classify focal segmental glomerulosclerosis (FSGS) specimens into the variants of the Columbia pathological classification. we considered that the evaluation method by LVSEM is probably useful the early histological diagnosis of FSGS.
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