2013 Fiscal Year Final Research Report
Study on the reperfused myocardial energy metabolism of congenital heart disease by lipidome search
| Project/Area Number |
23591578
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Pediatrics
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| Research Institution | Kyoto Prefectural University of Medicine |
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Principal Investigator |
OKA Tatsujiro 京都府立医科大学, 医学(系)研究科(研究院), 研究員 (80433283)
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| Co-Investigator(Kenkyū-buntansha) |
ITOI Toshiyuki 京都府立医科大学, 大学院医学研究科, 准教授 (10264780)
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| Project Period (FY) |
2011 – 2013
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| Keywords | 小児循環器学 / 先天性心疾患 / 虚血後再灌流 / リピドーム |
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| Research Abstract |
We successfully created a congenital heart disease model by low oxygen load and ventricular volume overload due to arteriovenous shunting created in rats. the extent of post-ischemic reperfusion injury of the heart was compared to a control model. Analysis of myocardial membrane fatty acids components were used nano-electrospray mass spectrometry and gas chromatography mass spectrometer. The n-3 poly-unsuturated fatty acids (PUFA) were increased and n-6 PUFA were reduced in congenital heart disease model by hypoxia load. C20:4 did not change but configuration of membrane lipids has changed from C18:2 to C22:6.
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[Journal Article] Cardiac hypertrophy in the newborn delays the maturation of fatty acidβ-oxidation and compromises postischemic functional recovery2012
Author(s)
Oka T, Lam VH, Zhang L, Keung W, Cadete VJ, Samokhvalov V, Tanner BA, Beker DL, Ussher JR, Huqi A, Jaswal JS, Rebeyka IM, Lopaschuk GD
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Journal Title
Am J Physiol Heart Circ Physiol
Volume: 302(9)
Pages: H1784-94
DOI
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[Journal Article] Stimulation of glucose oxidation protects against acute myocardial infarction and reperfusion injury2012
Author(s)
Ussher JR, Wang W, Gandhi M, Keung W, Samokhvalov V, Oka T, Wagg CS, Jaswal JS, Harris RA, Clanachan AS, Dyck JR, Lopaschuk GD
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Journal Title
Cardiovasc Res
Volume: 94(2)(Epub 2012 Mar 21)
Pages: 359-69
DOI
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