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2013 Fiscal Year Final Research Report

Experimental study on the pathogenesis of Kawasaki vasculitis

Research Project

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Project/Area Number 23591579
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeMulti-year Fund
Section一般
Research Field Pediatrics
Research InstitutionKyoto Prefectural University of Medicine

Principal Investigator

NAKAMURA Akihiro  京都府立医科大学, 医学部, 博士研究員 (50313854)

Co-Investigator(Kenkyū-buntansha) HAMAOKA Kenji  京都府立医科大学, 大学院医学研究科, 教授 (60189602)
Project Period (FY) 2011 – 2013
Keywords川崎病 / 真菌 / 動物モデル / 自然免疫
Research Abstract

Kawasaki disease (KD) is an idiopathic vasculitis in children. As its coronary sequela could be a risk factor of ischemic heart diseases in young adulthood, elucidation of its pathogenesis is one of the most important issues in cardiovasular medicine. Using Candida albicans water soluble extract (CAWS)-induced mouse model for KD, we got the following results: 1 ) IgM, MBLs and C3-derived peptides deposited in the inflamed vasculature. 2) IgM type autoantibody was increased in response to CAWS-stimulation. 3) the autoantibody recognized some specific endogenous proteins including a mitochondrial enzyme. These findings suggest that some specific infectious stimuli provoke innate humoral immunity to cause sterile vasculitis such as Kawasaki disease.

  • Research Products

    (6 results)

All 2014 2013 2012 2011

All Journal Article (2 results) (of which Peer Reviewed: 2 results) Presentation (4 results)

  • [Journal Article] Involvement of mannose-binding lectin in the pathogenesis of Kawasaki disease-like murine vasculitis2014

    • Author(s)
      Nakamura A, Okigaki M, Miura N, Suzuki C, Ohno N, kametani F, Hamaoka K
    • Journal Title

      Clin Immunol

      Volume: 153 Pages: 64-72

    • Peer Reviewed
  • [Journal Article] Utility of whole-blood aggregometry for evaluating anti-platelet therapy for Kawasaki disease2013

    • Author(s)
      Suzuki C, yahata T, Okamoto-Hamaoka A, Fujii M, Yoshioka A, Niwa Y, Ikeda K, Nakamura A, and Hamaoka K
    • Journal Title

      Pediatr Int

      Volume: 55 Pages: 550-4

    • Peer Reviewed
  • [Presentation] The involvement of vasa vasorum in development of vasculitis inthe Kawasaki disease animal model2013

    • Author(s)
      Okamoto-Hamaoka A, Fujii M, Suzuki C, Yahata T, Nakmaura A, Ikeda K, Takamastu T, Hamaoka K
    • Organizer
      47^<th> Annual Meeting of the Association for Europea Pediatric and Congenital Cardiology
    • Place of Presentation
      London
    • Year and Date
      20130522-25
  • [Presentation] Experimental study on etiological participation of oxidative stress in vasculitis by Kawasaki disease2012

    • Author(s)
      Suzuki C, Yahata T, Hamaoka A, Fujii M, Nakamura A, Miura N, Ikeda K, Hamaoka K
    • Organizer
      46^<th> Annual Meeting of the Association for Europea Pediatric and Congenital Cardiology
    • Place of Presentation
      Istanbul
    • Year and Date
      20120523-26
  • [Presentation] Possible involvement of natural immune systems in the pathogenesis of Kawasaki disease2012

    • Author(s)
      Nakamura A, Okigaki M, kametani F, Miura N, Ohno N, Hamaoka K
    • Organizer
      10th International Kawasaki Disease Symposium
    • Place of Presentation
      Kyoto, Japan
    • Year and Date
      20120207-10
  • [Presentation] カンジダ誘発川崎病様血管炎におけるIgM型自己抗体に関する免疫生化学的研究2011

    • Author(s)
      中村明宏(他4名)
    • Organizer
      第31回日本川崎病学会
    • Place of Presentation
      横浜
    • Year and Date
      20110930-1001

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Published: 2015-07-16  

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