2013 Fiscal Year Final Research Report
Disease specific therapy of polycystic kidney disease based on its pathophysiology considering the ubiquitin-proteasome proteolysis mechanism
| Project/Area Number |
23591580
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Pediatrics
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| Research Institution | Wakayama Medical University |
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Principal Investigator |
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| Co-Investigator(Kenkyū-buntansha) |
YOSHIKAWA Norishige 和歌山県立医科大学, 医学部, 教授 (10158412)
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| Project Period (FY) |
2011 – 2013
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| Keywords | 多発性嚢胞腎 / CPKマウス / ユビキチン・プロテアソーム / 上皮間葉移行(EMT) / 疾患特異的治療 |
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| Research Abstract |
Polycystic kidney disease is an inherited disease, which is the most frequent in our country, and is one of main causes of chronic renal failure. There are two types of polycystic kidney disease, autosomal dominant (ADPKD) and autosomal recessive (ARPKD).
In this study, we elucidated ubiquitin-proteasome proteolysis mechanism in multiple pathophysiology of polycystic kidney disease, and aimed to confirm the effect with modification of ubiquitin-proteasome proteolysis using the model animal for disease specific therapy development based on the pathophysiology of polycystic kidney disease to adapt it to human. We focused on ubiquitin E3 ligase family, Smurf1 and Smurf2.
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Research Products
(26 results)
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[Journal Article] 進行性腎障害に関する調査研究班多発性嚢胞腎分科会厚生労働省進行性腎障害調査研究班多発性嚢胞腎診療指針2010年8月(解説)2010
Author(s)
乳原善文,香村衡一,木村理,嶋村剛,田邉一成,土谷健,成田一衛,中西浩一,西尾妙織,奴田原紀久雄,野村信介,花岡一成,東原英二,堀江重郎,武藤智,望月俊雄
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Journal Title
日本腎臓学会誌
Volume: 53
Pages: 556-583
Peer Reviewed
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[Presentation] Smad3 Phosphorylated at Both Linker and COOH-Terminal Regions in Cyst-Lining Epithelia in cpk Mouse, a Model of ARPKD2013
Author(s)
Hama T, Nakanishi K, Mukaiyama H, Togawa H, Sato M, Shima Y, Miyajima M, Nozu K, Nagao S, Takahashi H, Iijima K, Yoshikawa N
Organizer
46^<th> Annual Meeting of the American Society of Nephrology
Place of Presentation
Atlanta, USA(JASN 24:303A)
Year and Date
20131107-10
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[Presentation] Possible contribution of fibrocytes to renal fibrosis in cpk mouse, a model of ARPKD2013
Author(s)
Hama T, Nakanishi K, Mukaiyama H, Sato M, Togawa H, Shima Y, Miyajima M, Takahashi H, Nagao S, Iijima K, Yoshikawa N
Organizer
15th Congress of the International Pediatric Nephrology Association
Place of Presentation
Shanghai, China
Year and Date
20130830-0903
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[Presentation] cpkマウス多発性嚢胞腎モデル腎線維化におけるfibrocyteの関与2013
Author(s)
浜武継,中西浩一,向山弘展,佐藤匡,戸川寛子,島友子,宮嶋正康,高橋久英,長尾静子,飯島一誠,吉川徳茂
Organizer
第48回日本小児腎臓病学会学術集会
Place of Presentation
徳島
Year and Date
20130628-29
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[Presentation] cpkマウスARPKDモデルにおける病的Smad3リン酸化2013
Author(s)
浜武継,中西浩一,向山弘展,戸川寛子,佐藤匡,島友子,宮嶋正康,野津寛大,高橋久英,長尾枝澄香,飯島一誠,吉川徳茂
Organizer
第21回嚢胞性腎疾患研究会
Place of Presentation
東京
Year and Date
2013-09-21
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[Presentation] cpkマウスにおける病的態・遺伝子診断小児嚢胞性腎疾患の病Smad3リン酸化2013
Author(s)
浜武継,中西浩一,向山弘展,戸川寛子,佐藤匡,島友子,宮嶋正康,野津寛大,高橋久英,長尾枝澄香,飯島一誠,吉川徳茂
Organizer
第22回発達腎研究会
Place of Presentation
高槻
Year and Date
2013-09-14
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[Presentation] Possible Contribution of Fibrocytes to Renal Fibrosis in Cpk Mouse, a Model of ARPKD2012
Author(s)
Hama T, Nakanishi K, Mukaiyama H, Togawa H, Shima Y, Miyajima M, Takahashi H, Nagao S, Iijima K, Yoshikawa N
Organizer
45^<th> Annual Meeting of the American Society of Nephrology
Place of Presentation
San Diego, USA(JASN 2012;23:596A)
Year and Date
20121101-04
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[Presentation] Acceleration of Smad3 phosphorylation at linker regions via c-Jun NH2-terminal kinase (JNK) in cyst-lining epithelial cells in cpk mouse, a model of ARPKD2011
Author(s)
Mukaiyama H, Nakanishi K, Hama T, Togawa H, Shima Y, Miyajima M, Takahashi H, Nagao S, Iijima K, Yoshikawa N
Organizer
44^<th> Annual Meeting of the American Society of Nephrology
Place of Presentation
Philadelphia, USA(JASN 22:576A)
Year and Date
20111108-13
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[Presentation] cpkマウスARPKDモデルにおける上皮間葉移行(EMT)2011
Author(s)
向山弘展,中西浩一,戸川寛子,濵武継,島友子,宮嶋正康,吉原大輔,長尾枝澄香,高橋久英,飯島一誠,吉川徳茂
Organizer
第54回日本腎臓学会学術総会
Place of Presentation
横浜
Year and Date
20110615-17
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