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2013 Fiscal Year Final Research Report

Molecular analysis of the pathophysiology basis of nephrotic syndrome

Research Project

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Project/Area Number 23591586
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeMulti-year Fund
Section一般
Research Field Pediatrics
Research InstitutionToho University

Principal Investigator

SEKINE Takashi  東邦大学, 医学部, 教授 (50255402)

Co-Investigator(Kenkyū-buntansha) KUNISHIMA Shinji  独立行政法人国立病院機構(名古屋医療センター臨床研究センター), 臨床研究セーター, 室長 (60373495)
KURIHARA Hidetake  順天堂大学, 医学部, 准教授 (80311976)
MIURA Kenichiro  東京大学, 医学部附属病院, 助教 (70408483)
Project Period (FY) 2011 – 2013
Keywords巣状糸球体硬化症 / myosin IIA / ポドサイト / 蛋白尿 / 細胞骨格タンパク
Research Abstract

To lucidate the pathophysiology of nephrotic syndrome, especially FSGS, we investigated myosin IIA. First, We determined the precise localization of myosin IIA; myosin IIA is located at the primary process and cell body of podocye. In human kidney diseases manifesting heavy proteinuria, only in the kidney specimen from the patients with FSGS, the level of expression o myosin IIA was decreased, while in those from other kidney disease patients were not changed. In rat PAN nephrosis model, the expression level of myosin IIA was decreased at day 11 when heavy proteinuria was observed. Taken together, myosin IIA play the very important role in the development of human idiopathic nephrotic syndrome, especially FSGS.

  • Research Products

    (11 results)

All 2014 2013 2012 2011

All Journal Article (9 results) (of which Peer Reviewed: 8 results) Presentation (2 results)

  • [Journal Article] Somatic mosaicism in MYH9 disorders : the need to carefully evaluate apparently healthy parents2014

    • Author(s)
      Kunishima S, Kitamura K, Matsumo T, Sekine T, Saito H
    • Journal Title

      British Journal of Haematology

      Volume: 165 Pages: 883–892

    • DOI

      10.1111/bjh.12797

    • Peer Reviewed
  • [Journal Article] Epithelial protein lost in neoplasm modulates platelet-derived growth factor-mediated adhesion and motility of mesangial cells2014

    • Author(s)
      Tsurumi H, Harita Y, Kurihara H, Kosako H, Hayashi K, Matsunaga A, Kajiho Y, Kanda S, Miura K, Sekine T, Oka A, Ishizuka K, Horita S, Hattori M, Hattori S, Igarashi T
    • Journal Title

      Kidney Int

      Volume: (Epub ahead of print)

    • DOI

      10.1038/ki.2014.85

    • Peer Reviewed
  • [Journal Article] Japanese Dent disease has a wider clinical spectrum than Dent disease in Europe/USA : genetic and clinical studies of 86 unrelated patients with low-molecular-weight proteinuria2014

    • Author(s)
      Sekine T, Komoda F, Miura K, Takita J, Shimadzu M, Matsuyama T, Ashida A, Igarashi T
    • Journal Title

      Nephrol Dial Transplant

      Volume: 29(2) Pages: 376-84

    • DOI

      10.1093/ndt/gft394

    • Peer Reviewed
  • [Journal Article] Podocyte expression of nonmuscle myosin heavy chain-IIA decreases in idiopathic nephrotic syndrome, especially in focal segmental glomerulosclerosis2013

    • Author(s)
      Miura K, Kurihara H, Horita S, Chikamoto H, Hattori M, Harita Y, Tsurumi H, Kajiho Y, Sawada Y, Sasaki S, Igarashi T, Kunishima S, Sekine T
    • Journal Title

      Nephrol Dial Transplant

      Volume: 28(12) Pages: 2993-3003

    • DOI

      10.1093/ndt/gft350

    • Peer Reviewed
  • [Journal Article] Mutational analyses of the ATP6V1B1 and ATP6V0A4 genes in patients with primary distal renal tubular acidosis2013

    • Author(s)
      Miura K, Sekine T, Takahashi K, Takita J, Harita Y, Ohki K, Park MJ, Hayashi Y, Tajima A, Ishihara M, Hisano M, Murai M, Igarashi T
    • Journal Title

      Nephrol Dial Transplant

      Volume: 28(8) Pages: 2123-30

    • DOI

      10.1093/ndt/gft216

    • Peer Reviewed
  • [Journal Article] ネフローゼ症候群の関連分子とpodocyte細胞骨格—Epstein症候群から学ぶ2013

    • Author(s)
      関根孝司
    • Journal Title

      日本小児科学会雑誌

      Volume: 117 Pages: 959-969

  • [Journal Article] SIRPαinteracts with nephrin at the podocyte slit diaphragm2012

    • Author(s)
      Kajiho Y, Harita Y, Kurihara H, Horita S, Matsunaga A, Tsurumi H, Kanda S, Sugawara N, Miura K, Sekine T, Hattori S, Hattori M, Igarashi T
    • Journal Title

      FEBS J

      Volume: 279(17) Pages: 3010-21

    • DOI

      10.1111/j.1742-4658.2012.08682.x

    • Peer Reviewed
  • [Journal Article] The long-term use of enalapril and hydrochlorothiazide in two novel mutations patients with Dent's disease type 12012

    • Author(s)
      Vaisbich MH, Henriques Ldos S, Igarashi T, Sekine T, Seki G, Koch VH
    • Journal Title

      J Bras Nefrol

      Volume: 34(1) Pages: 78-81

    • Peer Reviewed
  • [Journal Article] V2 vasopressin receptor (V2R) mutations in partial nephrogenic diabetes insipidus highlight protean agonism of V2R antagonists2012

    • Author(s)
      Takahashi K, Makita N, Manaka K, Hisano M, Akioka Y, Miura K, Takubo N, Iida A, Ueda N, Hashimoto M, Fujita T, Igarashi T, Sekine T, Iiri T
    • Journal Title

      J Biol Chem

      Volume: 287(3) Pages: 2099-106

    • DOI

      10.1074/jbc.M111.268797

    • Peer Reviewed
  • [Presentation] Identical twins of Epstein/Fechtner syndrome with MYH9 R702C mutaions2011

    • Author(s)
      Ohwada Y, Suzumura H, Sugita K, Kanou K, Arisaka O, Tomita S, Ueda U, Sekine T, Kunishima S
    • Organizer
      The 11th Asian Congress of Pediatric Nephrology
    • Place of Presentation
      Fukuoka, Japan
    • Year and Date
      2011-06-04
  • [Presentation] MYH9, the gene respossible for hereditary progressing nephritis, also cause idiopathic FSGS ?2011

    • Author(s)
      Sekine T
    • Organizer
      The 11th Asian Congress of Pediatric Nephrology
    • Place of Presentation
      Fukuoka, Japan
    • Year and Date
      2011-06-02

URL: 

Published: 2015-07-16  

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