2013 Fiscal Year Final Research Report
Evaluation of vascular smooth muscle cell function and response mechanism according to transformation from constitution type to secretion type in acute phase of vasculitis
Project/Area Number |
23591588
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Research Category |
Grant-in-Aid for Scientific Research (C)
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Allocation Type | Multi-year Fund |
Section | 一般 |
Research Field |
Pediatrics
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Research Institution | Nippon Medical School |
Principal Investigator |
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Co-Investigator(Kenkyū-buntansha) |
KATSUBE Yasuhiro 日本医科大学, 医学部, 准教授 (20246523)
FUKAZAWA Ryuji 日本医科大学, 医学部, 准教授 (80277566)
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Project Period (FY) |
2011 – 2013
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Keywords | 川崎病 |
Research Abstract |
I made a vasculitis animal model of the Kawasaki disease resemblance,and elucidated migration of a vascular smooth muscle cell from a media by the destruction of the inner elasticity band with a vasculitis histologically in the subendothelial site. Furthermore, the possibility that the vascular smooth muscle cell which migrated in the subendothelial site was transformed in a secretion type from a constitution type by the expression of transcriptional factors such as KLF5 and Egr-1 was suggested. But enough estimation was not accomplished about the function and response mechanism of a transformed vascular smooth muscle cell.
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