2013 Fiscal Year Final Research Report
Evaluation of oxidative stress in children with non-alcoholic steatohepatitis
| Project/Area Number |
23591589
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Pediatrics
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| Research Institution | Osaka Medical College |
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Principal Investigator |
TAMAI HIROSHI 大阪医科大学, 医学部, 教授 (30179874)
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| Co-Investigator(Kenkyū-buntansha) |
TAKITANI Kimitaka 大阪医科大学, 医学部, 講師 (80319540)
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| Project Period (FY) |
2011 – 2013
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| Keywords | 非アルコール性脂肪性肝疾患 / 非アルコール性脂肪肝炎 / 抗酸化剤 |
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| Research Abstract |
Non-alcoholic fatty liver disease (NAFLD) is the most common liver disorder in developed countries, and its incidence is increasing in adults and children. As an antioxidant, vitamin E is effective in treatment of NAFLD, although the mechanism is still unclear. Methionine-choline deficient (MCD) rats used as an experimental model of NAFLD were fed a vitamin E-enriched diet. In the MCD rats, vitamin E treatment altered the hepatic alpha-tocopherol-related protein expression, which may affect the alpha-tocopherol status in the liver and reduce lipid peroxidation.
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[Journal Article] Utstein Osaka Project. Age-specific differences in outcomes after out-of-hospital cardiac arrests2011
Author(s)
Nitta M, Iwami T, Kitamura T, Nadkarni VM, Berg RA, Shimizu N, Ohta K, Nishiuchi T, Hayashi Y, Hiraide A, Tamai H, Kobayashi M, Morita H
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Journal Title
Pediatrics
Volume: 128
Pages: e812-20
DOI
Peer Reviewed
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