2015 Fiscal Year Final Research Report
Evaluation of Plasma Concentration of the Antiarrhythmic Agent for Treatment of Fetus Tachycardia
| Project/Area Number |
23591607
|
|---|
| Research Category |
Grant-in-Aid for Scientific Research (C)
|
| Allocation Type | Multi-year Fund |
|---|
| Section | 一般 |
|---|
| Research Field |
Embryonic/Neonatal medicine
|
|---|
| Research Institution | Kinki University |
|---|
Principal Investigator |
|
|---|
| Research Collaborator |
KATSURAGI Shinji
IKEDA Tomoaki
|
|---|
| Project Period (FY) |
2011-04-28 – 2016-03-31
|
| Keywords | 胎児不整脈 / 抗不整脈薬 / 薬物血中濃度 / 経胎盤的胎児治療 |
|---|
| Outline of Final Research Achievements |
This study was conducted in 32 hospitalized patients (average age 31.2, average weight 59.0) to investigate pharmacokinetics and pharmacodynamic. The mean cord blood/maternal plasma concentration of DX (16 examples) and ST (7 examples) was 67.6% and 73.9%, respectively.As for the dosage, a correlation was found in both DX plasma concentrations (26 examples) (P<0.001) and ST plasma concentration (12 examples) (P=0.04). There was a correlation tendency between DX plasma concentration and serum creatinine (Scr) (P=0.06), was not a significant correlation between ST plasma concentration and Scr (P=0.18). Furthermore, maternal heart rate related to DX plasma concentration weakly (P=0.09), but did not relate to ST plasma concentration (P=0.51). Treatment of fetus tachycardia made fetal atrial heart rate decreased like log approximation.
It is expected to apply for approval of health insurance treatment by analyzing more additional target cases.
|
| Free Research Field |
医療薬剤
|
