2013 Fiscal Year Final Research Report
Development of new anticancer therapy utilizing the innate immunity
| Project/Area Number |
23591611
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Dermatology
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| Research Institution | Hirosaki University |
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Principal Investigator |
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| Co-Investigator(Kenkyū-buntansha) |
SAWAMURA Daisuke 弘前大学, 大学院医学研究科, 教授 (60196334)
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| Project Period (FY) |
2011 – 2013
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| Keywords | メラノーマ / RIG-I |
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| Research Abstract |
I confirmed that cultured melanoma cells expressed RIG-I protein by IFN-beta stimulation. Moreover, proliferation activities of melanoma cells were suppressed by IFN-beta. Poly-(I:C), known as synthetic analog of double-stranded RNA, has no effect on the induction of RIG-I expression in the human melanoma cells.
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