Investigation of two-step theory involved with TIF1-gamma in cancer-associated with dermatomyositis

2014 Fiscal Year Final Research Report

• Project/Area Number: 23591618
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Multi-year Fund
• Section: 一般
• Research Field: Dermatology
• Research Institution: Nagoya University
• Principal Investigator: MURO YOSHINAO 名古屋大学, 医学(系)研究科(研究院), 准教授 (80270990)
• Co-Investigator(Kenkyū-buntansha): SUGIURA Kazumitsu 名古屋大学, 医学系研究科, 准教授 (70335032) ; OGAWA Yasushi 名古屋大学, 医学部附属病院, 助教 (10567754)
• Project Period (FY): 2011-04-28 – 2015-03-31
• Keywords: 皮膚筋炎 / 悪性腫瘍 / 抗TIF1-γ抗体

Outline of Final Research Achievements

The pathogenic mechanisms has been still unknown in cancer-associated dermatomyositis (CADM). We investigated whether malignant tissues in CADM have the aberrant expression of TIF1-γ, which is a serological marker of CADM, and also investigated the possibility of interaction between TIF1-γ, and TGFβand other associated molecules. We showed the high expression of TIF1-γ
in malignant tissues in patients with anti-TIF1-γ and suggested the possibility of tumor growth by the phosphorylation of STAT3 through IL-6.

Free Research Field

皮膚科学