2013 Fiscal Year Final Research Report
The influence of the innate immune system on the barrier function of the stratum corneum of the skin
| Project/Area Number |
23591637
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Dermatology
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| Research Institution | Tohoku University |
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Principal Investigator |
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| Co-Investigator(Kenkyū-buntansha) |
YAMASAKI Kenshi 東北大学, 医学系研究科, 准教授 (40294798)
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| Project Period (FY) |
2011 – 2013
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| Keywords | 皮膚バリア機能 / 角層 / 自然免疫 / アトピー性皮膚炎 / 尋常性ざ瘡 / 脂漏性皮膚炎 / 酒さ |
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| Research Abstract |
The barrier function of the skin on the face is deteriorated as compared to that of the skin of other part and rosacea, acne and seborrheic dermatitis are often observed on the face. The lipophilic skin flora such as p. acnes and malassezia have been implicated as causative agents of acne, rosacea and seborrheic dermatitis, respectively. In healthy control, the skin surface lipid level on the eyelid skin and earlobe skin, where rosacea and seborrheic dermatitis hardly observed, found to be significantly lower than on the cheek skin. In addition to the higher skin surface lipid level, the barrier function of the stratum corneum on the perioral skin assessed by TEWL was found to be more deteriorated than on the cheek. The impaired barrier function on the perioral skin might affect to the development of the perioral dermatitis, related disorder to rosacea.
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J Invest Dermatol
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[Journal Article] Cathelicidin, kallikrein 5, and serine protease activity is inhibited during treatment of rosacea with azelaic acid 15% gel2013
Author(s)
Coda, A. B., Hata, T., Miller, J., Audish, D., Kotol, P., Two, A., Shafiq, F., Yamasaki, K., Harper, J. C., Del Rosso, J. Q., and Gallo, R. L.
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Morizane, S., Yamasaki, K., Muhleisen, B., Kotol, P. F., Murakami, M., Aoyama, Y., Iwatsuki, K., Hata, T., and Gallo, R. L.
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J Invest Dermatol
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[Journal Article] TH2 cytokines increase kallikrein 7 expression and function in patients with atopic dermatitis2012
Author(s)
Morizane, S., Yamasaki, K., Kajita, A., Ikeda, K., Zhan, M., Aoyama, Y., Gallo, R. L., and Iwatsuki, K.
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Journal Title
J Allergy Clin Immunol
Volume: 130
Pages: 259-261, e251
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[Journal Article] TLR2 expression is increased in rosacea and stimulates enhanced serine protease production by keratinocytes2011
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[Journal Article] An in vitro test to screen skin sensitizers using a stable THP-1-derived IL-8 reporter cell line, THP-G82011
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Journal Title
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Pages: 359-369
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[Journal Article] Exogenous addition of a C-xylopyranoside derivative stimulates keratinocyte dermatan sulfate synthesis and promotes migration2011
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Muto, J., Naidu, N. N., Yamasaki, K., Pineau, N., Breton, L., and Gallo, R. L.
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Journal Title
PLoS One
Volume: 6
Pages: e25480
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Peer Reviewed
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