2013 Fiscal Year Final Research Report
Visualization of transepidermal invasion of fluorescent HIV and development of the new HIV entry inhibitor
| Project/Area Number |
23591641
|
|---|
| Research Category |
Grant-in-Aid for Scientific Research (C)
|
| Allocation Type | Multi-year Fund |
|---|
| Section | 一般 |
|---|
| Research Field |
Dermatology
|
|---|
| Research Institution | University of Yamanashi |
|---|
Principal Investigator |
|
|---|
| Project Period (FY) |
2011 – 2013
|
| Keywords | 性行為HIV感染 / Langerhans cells / Maraviroc / EFdA |
|---|
| Research Abstract |
It became clear that Langerhans cells (LCs) in the epidermis of volunteer, who took Maraviroc (MVC), had very strong resistance for HIV infection, suggesting that MVC; the agent developed as an AIDS therapeutic drug has been demonstrated as a useful oral micro beside. In addition, in the in vitro HIV infection experiment with monocyte-derived LCs, it was suggested that EFdA and MVC had a superior suppressant effect against HIV infection, and that EFdA can be practically used as micro beside.
|
-
-
[Journal Article] Case of primary cutaneous peripheral T-cell lymphoma, not otherwise specified, with characteristics of follicular helper T cells2014
Author(s)
Takaki M, Inozume T, Matsuzawa T, Ando N, Yamaguchi M, Harada K, Kawamura T, Shibagaki N, Shimada S
-
Journal Title
J Dermatol
Volume: (In press)
DOI
Peer Reviewed
-
[Journal Article] EFdA, a reverse transcriptase inhibitor, potently blocks HIV-1 ex vivo infection of Langerhans cells within epithelium2014
Author(s)
Matsuzawa T, Kawamura T, Ogawa Y, Maeda K, Nakata H, Moriishi K, Koyanagi Y, Gatanaga H, Shimada S, Mitsuya H
-
Journal Title
J Invest Dermatol
Volume: 134(4)
Pages: 1158-61
DOI
Peer Reviewed
-
[Journal Article] Oral administration of the CCR5 inhibitor, maraviroc, blocks HIV ex vivo infection of Langerhans cells within the epithelium2013
Author(s)
Matsuzawa T, Kawamura T, Ogawa Y, Takahashi M, Aoki R, Moriishi K, Koyanagi Y, Gatanaga H, Blauvelt A, Shimada S
-
Journal Title
J Invest Dermatol
Volume: 133(12)
Pages: 2803-5
DOI
Peer Reviewed
-
-
-
-
[Journal Article] Antimicrobial peptide LL-37 produced by HSV-2-infected keratinocytes enhances HIV infection of Langerhans cells2012
Author(s)
Ogawa Y, Kawamura T, Matsuzawa T, Aoki R, Gee P, Yamashita A, Moriishi K, Yamasaki K, Koyanagi Y, Blauvelt A, Shimada S
-
Journal Title
Cell Host Microbe
Volume: 13(1)
Pages: 77-86
DOI
Peer Reviewed
-
-
-
-
-
[Journal Article] Severe dermatitis with loss of epidermal Langerhans cells in human and mouse zinc deficiency2012
Author(s)
Kawamura T, Ogawa Y, Nakamura Y, Nakamizo S, Ohta Y, Nakano H, Kabashima K, Katayama I, Koizumi S, Kodama T, Nakao A, Shimada S
-
Journal Title
J Clin Invest
Volume: 122(2)
Pages: 722-32
DOI
Peer Reviewed
-
-
-
