2013 Fiscal Year Final Research Report
Skin regeneration - Signal transduction in hair follicles
| Project/Area Number |
23591644
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Dermatology
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| Research Institution | Osaka University |
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Principal Investigator |
ITAMI SATOSHI 大阪大学, 医学(系)研究科(研究院), 寄附講座教授 (30136791)
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| Co-Investigator(Kenkyū-buntansha) |
INUI Shigeki (30324750)
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| Project Period (FY) |
2011 – 2013
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| Keywords | 毛包 / 幹細胞 / 毛周期 / 男性ホルモン / 再生医学 / MED1 |
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| Research Abstract |
1.Lrig1, a negative feedback regulator of the ErbB receptor family, was highly expressed by hair follicle and intestinal stem cells and controls the size of their niche by regulating the amplitude of growth factor signalling. MED1 is expressed by human epidermal keratinocytes and functions as a coactivator of several transcription factors. Med1 knockout mice provided an strong evidece that MED1 plays an important role in maintaining quiescence of keratinocytes and preventing depletion of the follicular stem cells.
2.Production of leptin, a well-known adipokine, by dermal papilla cells increased under hypoxic condition, suggesting that hypoxia in catagen/telogen phase promotes leptin production by dermal papilla, preparing for entry into the next anagen.
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[Journal Article] Induction of transforming growth factor-beta 1 by androgen is mediated by reactive oxygen species in hair follicle dermal papilla cells2013
Author(s)
Shin H, Yoo HG, Inui S, Itami S, Kim IG, Cho AR, Lee DH, Park WS, Kwon O, Cho KH, Won CH
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Journal Title
BMB Rep
Volume: 46(9)
Pages: 460-4
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[Journal Article] Lrig1 controls intestinal stem-cell homeostasis by negative regulation of ErbB signaling2012
Author(s)
Wong VW, Stange DE, Page ME, Buczacki S, Wabik A, Itami S, van de Wetering M, Poulsom R, Wright NA, Trotter MW, Watt FM, Winton DJ, Clevers H, Jensen KB
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Journal Title
Nat Cell Biol
Volume: 14
Pages: 401-8
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