2013 Fiscal Year Final Research Report
Does fibronectin activated by dermatopontin have anti-tumor activity?
| Project/Area Number |
23591648
|
|---|
| Research Category |
Grant-in-Aid for Scientific Research (C)
|
| Allocation Type | Multi-year Fund |
|---|
| Section | 一般 |
|---|
| Research Field |
Dermatology
|
|---|
| Research Institution | Oita University |
|---|
Principal Investigator |
|
|---|
| Co-Investigator(Kenkyū-buntansha) |
FUJIWARA Sakuhei 大分大学, 医学部, 教授 (90181411)
|
|---|
| Co-Investigator(Renkei-kenkyūsha) |
MATSUO Noritaka 大分大学, 医学部, 准教授 (10284788)
|
|---|
| Project Period (FY) |
2011 – 2013
|
| Keywords | 細胞外マトリックス |
|---|
| Research Abstract |
We found that dermatopontin interacts with fibronectin and activates it (Kato, J. Biol. Chem. 2011, Okamoto, Astetic Dermatol. 2011). The activated fibronectin decreased the number of vessels in melanoma tumor inoculated on the back of mice.
We also found that dermatopontin interacts with fibrinogen. Dermatopontin accelerated fibrin fibril formation and the diameters of newly-formed fibrin fibrils became greater than those formed under normal condition. The fibrin fibrils enhanced human umbilical vein endothelial cell adhesion and the cell spreading (Wu, J. Invest. Dermatol. 2014).
|
Research Products
(12 results)
-
-
[Journal Article] Dermatopontin Interacts with Fibronectin,Promotes Fibronectin Fibril Formation,and Enhances Cell Adhesion2011
Author(s)
Kato A,Okamoto O,Ishikawa K,Sumiyoshi H,Matsuo N,Yoshioka H,Nomizu M,Shimada T,and Fujiwara S
-
Journal Title
The Journal of Biological Chemistry
Volume: 286(17)
Pages: 14861-14869
-
-
-
-
-
-
-
-
-
-
