2013 Fiscal Year Final Research Report
Cutaneous immunoregulatory functions of a novel antimicrobial agent, catestatin
| Project/Area Number |
23591655
|
|---|
| Research Category |
Grant-in-Aid for Scientific Research (C)
|
| Allocation Type | Multi-year Fund |
|---|
| Section | 一般 |
|---|
| Research Field |
Dermatology
|
|---|
| Research Institution | Juntendo University |
|---|
Principal Investigator |
NIYONSABA FRANCOIS 順天堂大学, 医学(系)研究科(研究院), 准教授 (60365640)
|
|---|
| Project Period (FY) |
2011 – 2013
|
| Keywords | 抗菌ペプチド / 皮膚免疫 / 自然免疫 / ケラチノサイト / 好中球 |
|---|
| Research Abstract |
Catestatin, initially believed to act as an neuroendocrine regulator, is an antimicrobial agent found in the skin keratinocytes and fibroblasts, and is over-expressed during wound healing and infection. In this study, we observed that Catestatin and the newly discovered antimicrobial peptides known as IDRs stimulated various functions of human keratinocytes and neutrophils, leading to the wound healing acceleration. Thus, in addition to their microbiocidal properties, skin-derived antimicrobial agents might also participate to the regulation of cutaneous host defense, inflammation and innate immune system through activation of keratinocytes.
|
