2013 Fiscal Year Final Research Report
Elucidation of ultraviolet radiation-induced physiological degradation pathway of eumelanin and pheomelanin
| Project/Area Number |
23591659
|
|---|
| Research Category |
Grant-in-Aid for Scientific Research (C)
|
| Allocation Type | Multi-year Fund |
|---|
| Section | 一般 |
|---|
| Research Field |
Dermatology
|
|---|
| Research Institution | Fujita Health University |
|---|
Principal Investigator |
ITO Shosuke 藤田保健衛生大学, その他部局等, 名誉教授 (70121431)
|
|---|
| Co-Investigator(Kenkyū-buntansha) |
WAKAMATSU Kazumasa 藤田保健衛生大学, 医療科学部, 教授 (80131259)
|
|---|
| Project Period (FY) |
2011 – 2013
|
| Keywords | メラニン / 紫外線 / 可視光線 / ユーメラニン / フェオメラニン / UVA / UVB |
|---|
| Research Abstract |
Melanin is classified into black eumelanin and reddish pheomelanin. Our study aimed at elucidating UV-induced physiological degradation of both melanins. Using human black hair and red hair, we found that eumelanin is degraded to give PTCA (pyrrole-2,3,5-tricarboxylic acid) while pheomelanin is changed from benzothiazine to benzothiazole structure. Next, using mouse hair and human hair and synthetic eumelanin and pheomelanin, we found similar changes in structure of melanin upon UVA irradiation. Finally, using cultured melanocytes and retinal pigment epithelial cells, we showed that eumelanin gives rise to cross-linking structure upon UVA or visible light irradiation.
|
-
-
[Journal Article] Variants in melanogenesis-related genes associate with skin cancer risk among Japanese populations2014
Author(s)
Yoshizawa J, Abe Y, Oiso N, Fukai K, Hozumi Y, Nakamura T, Narita T, Motokawa T, Wakamatsu K, Ito S, Kawada A, Tamiya G, Suzuki T
-
Journal Title
J Dermatol
Volume: 41
Pages: 296-302
-
-
[Journal Article] TLR4 and NLRP3 inflammasome activation in monocytes by N-propionyl cysteaminylphenol- maleimide-dextran (NPCMD)2014
Author(s)
Mizote Y, Wakamatsu K, Ito S, Uenaka A, Ohue Y, Kurose K, Isobe M, Ito A, Tamura Y, Honda H, Yamashita T, Nohara S, Oka M, Jimbow K, Nakayama E
-
Journal Title
J Dermatol Sci
Volume: 73
Pages: 209-215
-
-
[Journal Article] Impact of diagenesis and maturation on the survival of eumelanin in the fossil record2013
Author(s)
Glass K, Ito S, Wilby PR, Sota T, Nakamura A, Bowers CR., Miller KE, Dutta S, Summons RE, Briggs DEG, Wakamatsu K, Simon JD
-
Journal Title
Organic Geochem
Volume: 64
Pages: 29-37
-
-
-
-
[Journal Article] Photoaging of human retinal pigment epithelium is accompanied by oxidative modification of its eumelanin2013
Author(s)
Ito S, Pilat A, Gerwat W, Skumatz CMB, Ito M, Kiyono A, Zadlo A, Nakanishi Y, Kolbe L, Burke JM, Sarna T, Wakamatsu K
-
Journal Title
Pigment Cell Melanoma Res
Volume: 26
Pages: 357-366
-
-
-
-
-
-
-
[Journal Article] T-cell recepter repertoires of tumor-infiltrating lymphocytes after hyperthermia using functinalized magnetite nanopartcicles2012
Author(s)
Ito A, Yamaguchi M, Okamoto N, Sanematsu Y, Kawabe Y, Wakamatsu K, Ito S, Honda H, Kobayashi T, Nakayama E, Tamura Y, Okura M, Yamashita T, Jimbow K, Kamihira M
-
Journal Title
Nanomedicine (London)
Volume: 8
Pages: 891-902
-
[Journal Article] Mechanism of putative neo-antigen formation from N-Propionyl-4-S-cysteaminylphenol, a tyrosinase substrate, in melanoma models2012
Author(s)
Ito S, Nishigaki A, Ishii-Osai Y, Ojika M, Wakamatsu K, Yamashita T, Tamura Y, Ito A, Honda H, Nakayama E, Jimbow K
-
Journal Title
Biochem Pharmacol
Volume: 84
Pages: 646-653
-
[Journal Article] N-Propionyl-4-S- cysteaminylphenol induces apoptosis in B16F1 cells and mediated tumor-specific T-cell immune responses in a mouse melanoma model2012
Author(s)
Ishii-Osai Y, Yamashita T, Tamura Y, Sato N, Ito A, Honda H, Wakamatsu K, Ito S, Nakayama E, Okura M, Jimbow K
-
Journal Title
J Dermatol Sci
Volume: 67
Pages: 51-60
-
-
[Journal Article] Cystinosin is a melanosomal protein that regulates melanin synthesis2012
Author(s)
Chiaverini C, Sillard L, Flori E, Ito S, Wakamatsu K, Briganti S, Fontas E, Bernard E, Cailliez M, Cochat P, Foulard M, Guest G, Niaudet P, Picard M, Bernard FX, Antignac C, Ortonne JP, Ballotti R
-
Journal Title
FASEB J
Volume: 26
Pages: 3779-3789
-
[Journal Article] Direct chemical evidence for eumelanin pigment from the Jurassic period2012
Author(s)
Glass, K, Ito S, Wilby PR, Sota T, Nakamura A, Bowers CR, Vinther JV, Dutta S, Summons R, Briggs DEG, Wakamatsu K, Simon JD
-
Journal Title
Proc Natl Acad Sci
Volume: 109
Pages: 10218-10223
-
-
-
-
-
-
[Journal Article] Inactivation of pmel alters melanosome shape but has only a subtle effect on visible pigmentation2011
Author(s)
Hellström AR, Watt B, Fard SS, Tenza D, Mannström P, Narfström K, Ekesten B, Ito S, Wakamatsu K, Larsson J, Ulfendahl M, Kullander K, Raposo G, Kerje S, Hallböök F, Marks MS, Andersson L
-
Journal Title
PLos Genet
Volume: 7
Pages: e1002285
-
-
-
-
[Journal Article] 1-(2,4-Dihydroxyphenyl)-3-(2,4-dimetho xy-3-methylphenyl) propane inhibits melanin synthesis by dual mechanism2011
Author(s)
Niki Y, Yoshida M, Ando H, Wakamatsu K, Ito S, Harada N, Matsui MS, Yarosh DB, Ichihashi M
-
Journal Title
J Dermatol Sci
Volume: 63
Pages: 115-121
-
-
-
-
-
-
-
-
