2013 Fiscal Year Final Research Report
Functional effects of IL-33 on skin tissue cells
| Project/Area Number |
23591666
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Dermatology
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| Research Institution | National Research Institute for Child Health and Development |
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Principal Investigator |
MATSUDA Akio 独立行政法人国立成育医療研究センター, 免疫アレルギー研究部, 室長 (10359705)
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| Co-Investigator(Kenkyū-buntansha) |
FUTAMURA Kyoko 独立行政法人国立成育医療研究センター, 免疫アレルギー研究部, 研究員 (60596956)
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| Project Period (FY) |
2011 – 2013
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| Keywords | IL-33 / 皮膚組織細胞 / 皮膚炎症 |
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| Research Abstract |
The IL-1-like cytokine IL-33 is constitutively expressed in the nucleus of barrier tissue cells such as epithelial cells and endothelial cells. IL-33 passively released from damaged tissue has been shown to be acted as a cytokine. We found that IL-33 can act on epidermal keratinocytes and dermal microvascular endothelial cells to induce neutrophil-associated cytokine/chemokine productions.
Furthermore, we have established an in vitro scratch model of skin tissue cells, and found that keratinocyte extracts contained unidentified pro-inflammatory substances to mediate inflammatory responses to intact cultured skin tissue cells such as fibroblasts and microvascular endothelial cells. These findings suggest the existence of a molecular machinery of "itch-scratch cycle" in the inflammatory skin diseases such as atopic dermatitis.
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[Journal Article] Silica and double-stranded RNA Synergistically induce bronchial epithelial apoptosis and airway inflammation2014
Author(s)
Unno, H., K. Futamura, H. Morita, R. Kojima, K. Arae, S. Nakae, H. Ida, H. Saito, K. Matsumoto, A. Matsuda
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Journal Title
Am J Respir Cell Mol Biol
Volume: (in press)
DOI
Peer Reviewed
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[Journal Article] Galectin-9 enhances cytokine secretion, but suppresses survival and degranulation, in human mast cell line2014
Author(s)
Kojima, R., T. Ohno, M. Iikura, T. Niki, M. Hirashima, K. Iwaya, H. Tsuda, S. Nonoyama, A. Matsuda, H. Saito, K. Matsumoto, and S. Nakae
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Journal Title
PLoS One
Volume: 9(1)
Pages: e86106
DOI
Peer Reviewed
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[Journal Article] Antigen-specific T-cell responses in patients with non-IgE-mediated gastrointestinal food allergy are predominantly skewed to T(H)22013
Author(s)
Morita, H., I. Nomura, K. Orihara, K. Yoshida, A. Akasawa, H. Tachimoto, Y. Ohtsuka, Y. Namai, M. Futamura, T. Shoda, A. Matsuda, N. Kamemura, H. Kido, T. Takahashi, Y. Ohya, H. Saito, and K. Matsumoto
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Journal Title
J Allergy Clin Immunol
Volume: 131(2)
Pages: 590-2 e1-6
DOI
Peer Reviewed
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[Journal Article] ST2 requires Th2-, but not Th17-, type airway inflammation in epicutaneously antigen- sensitized mice2012
Author(s)
Morita, H., K. Arae, T. Ohno, N. Kajiwara, K. Oboki, A. Matsuda, H. Suto, K. Okumura, K. Sudo, T. Takahashi, K. Matsumoto, and S. Nakae
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Journal Title
Allergol Int
Volume: 61(2)
Pages: 265-73
DOI
Peer Reviewed
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[Presentation] Interleukin-33 and thymic stromal lymphopoietin are preferentially elevated in the sera of infants with eosinophilic gastroenteritis2014
Author(s)
Nomura I, Matsuda A, Shoda T, Morita H, Arai K, Shimizu H, Yamada Y, Ohya Y, Saito H, Matsumoto K
Organizer
Annual meeting of the American Academy of Allergy, Asthma and Immunology
Place of Presentation
San Diego, CA
Year and Date
2014-03-04
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[Presentation] Distinct differences between cluster 3 and 4 of non-IgE-mediated gastrointestinal allergy in allergen-specific lymphocyte proliferation test and histological findings of the GI mucosa2013
Author(s)
Nomura I, Morita H, Shoda T, Morita K, Matsuda A, Shimizu H, Arai K, Nakazawa A, Ohya Y, Saito H, Matsumoto K
Organizer
Annual meeting of the American Academy of Allergy, Asthma and Immunology
Place of Presentation
San Antonio, TX
Year and Date
2013-02-25
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