Effect of antipsychotics on metabolic and cardiac side effects in Japanese patients with schizophrenia

2014 Fiscal Year Final Research Report

• Project/Area Number: 23591670
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Multi-year Fund
• Section: 一般
• Research Field: Psychiatric science
• Research Institution: Niigata University
• Principal Investigator: SUZUKI Yutaro 新潟大学, 医歯学総合病院, 講師 (60377158)
• Co-Investigator(Kenkyū-buntansha): SOMEYA Toshiyuki 新潟大学, 医歯学系, 教授 (50187902) ; FUKUI Naoki 新潟大学, 医歯学系, 助教 (90535163)
• Project Period (FY): 2011-04-28 – 2015-03-31
• Keywords: antipsychotics / metabolic side effect / adipokine / genetic polymorphism / obesity / schizophrenia

Outline of Final Research Achievements

The side effects arising from treatment with antipsychotic drugs, such as obesity and glycolipid metabolism disorder are major side effects that affect the vital prognosis in schizophrenia patients, but their pathology and prevention methods remain unknown. The present research clarifies the following matters, contributing to the prevention of the serious side effects of antipsychotic drugs: (1) There are differences in the frequency at which such risks occur during the administration of antipsychotic drugs; (2) It is possible to predict obesity and glycolipid metabolism disorder from the blood adipokine concentration and genetic polymorphism.

Free Research Field

臨床精神薬理