2013 Fiscal Year Final Research Report
NrCAM associated neural network underlying addiction
| Project/Area Number |
23591671
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Psychiatric science
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| Research Institution | University of Yamanashi |
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Principal Investigator |
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| Project Period (FY) |
2011 – 2013
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| Keywords | NrCAM / 神経接着因子 / 依存 / 遺伝子発現プロファイリング / グルタミン酸神経 / GABA神経 / ストレス |
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| Research Abstract |
Substance dependence shows certain personality or behavioral characteristics, besides compulsiveness to drugs. Therefore, patients need effective medication in addition to psychotherapy to the psychosocial aspects of addiction. We therefore attempted to clarify NrCAM-related neural molecule network to contribute to the development of new therapeutics, because there is a few effective drugs used in present clinics. Result from the gene expression analysis using Nrcam knock-out mice treated with/without methamphetamine indicated several candidate genes involved in methamphetamine abuse. They included glutamatergic, GABAergic molecules and also stress-related molecules, which may be new therapeutic targets for addiction and its related personality behaviors.
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