2013 Fiscal Year Final Research Report
Possible antipsychotic effects of minocycline in patients with schizophrenia
| Project/Area Number |
23591673
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Psychiatric science
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| Research Institution | Shimane University |
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Principal Investigator |
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| Project Period (FY) |
2011 – 2013
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| Keywords | 統合失調症 / 神経炎症 |
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| Research Abstract |
We concluded that the Gunn rat, which exhibits a high concentration of unconjugated bilirubin, may be useful as an animal model of schizophrenia. On the other hand, there have been numerous reports that minocycline is effective in treating schizophrenia.
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[Journal Article] Efficacy and safety of yokukansan in treatment-resistant schizophrenia : a randomized,double-blind,placebo-controlled trial(a Positive and Negative Syndrome Scale, five-faotor analisis)2014
Author(s)
Miyaoka T, Furuya M, Horiguchi J, Wake R, Hashioka S, Tohyama M, Mori N, Minabe Y, Iyo M, Ueno S, Ezoe S, Murotani K, Hoshino S, Seno H
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Journal Title
Psychopharmacology(Berl)
Volume: (in press)
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[Journal Article] The Effects of combine treatment of memantine and donepezil on Alzheimer's Disease patients and its relationship with cerebral blood flow in the prefrontal area2014
Author(s)
Araki T, Wake R, Miyaoka T, Kawakami K, Nagahama M, Furuya M, Limoa E, Liaury K, Hashioka S, Murotani K, Horiguchi J
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Journal Title
Int J Geriatr Psychiatry
Volume: (in press)
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[Journal Article] Minocycline improves recognition memory and attenuates microglial activation in Gunn rat : a possible hyperbilirubinemia-induced model of schizophrenia2014
Author(s)
Liaury K, Miyaoka T, Tsumori T, Furuya M, Hashioka S, Wake R, Tsuchie K, Fukushima M, Limoa E, Tanra AJ, Horiguchi J
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Journal Title
Prog Neuropsychopharmacol Biol Psychiatry
Volume: 50
Pages: 184-190
Peer Reviewed
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[Journal Article] Yokukansan (TJ-54) forIrritability Associated with Pervasive Developmental Disorder in Children and Adolescents : A 12-Week Prospective, Open-Label Study2013
Author(s)
Wake R, MD, Miyaoka T, Inagaki T, MD, Furuya M, Ieda M, MD, Liaury K, MD, Kishi K, Horiguchi J
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Journal Title
JOURNAL OF CHILD AND ADOLESCENT PSYCHOPHARMACOLOGY
Volume: 23(5)
Pages: 329-336
Peer Reviewed
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[Journal Article] Yokukansan(TJ-54) for treatment of very-late-onset schizophrenia-like psychosis : An open-label study2013
Author(s)
Miyaoka T, Wake R, Furuya M, Liaury K, Ieda M, Kawakami K, Tsuchie K, Fukushima M, Ishihara K, Araki T, Hashioka S, Horiguchi J
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Journal Title
Phytomedicine
Volume: 20(7)
Pages: 654-658
Peer Reviewed
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[Presentation] Efficacy and safety of yokukansan (TJ-54) for treatment-resistant schizophrenia : a randomised placebo-controlled trial2013
Author(s)
Miyaoka T, Furuya M, Horiguchi J, Wake R, Hayashida S, Toyama M, Daimon T, Mori N, Minabe Y, Iyo M
Organizer
26th ECNP
Place of Presentation
Barcelona, Spain
Year and Date
20131005-09
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[Presentation] Efficacy and Safety of Yokukansan (TJ-54) for Treatment-Resistant Schizophrenia : A Randomized, Multi-centre, Double-blind, Placebo-controlled Trial2013
Author(s)
Miyaoka T, Furuya M, Horiguchi J, Wake R, Hashioka J, Toyama M, Daimon T, Mori N, Minabe Y, Iyo M, Ueno S, Ezoe S, Hoshino S, Seno H
Organizer
Society of Biological Psychiatry 68th Annual Meeting
Place of Presentation
(San Francisco) California
Year and Date
20130516-18
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[Presentation] Yokukansan Promote Hippocampal Neurogenesis Through The Inhibition of Microglial Activation in Rodents with Hyperbillirubinemia : a neuroinflammational animal model of schizophrenia2013
Author(s)
Furuya M, Miyaoka T, Tsumori T, Hashioka S, Wake R, Liaury K, Ieda M, Ishihara K, Tsuchie K, Fukushima M, Araki T, Ezoe S, Horiguchi J
Organizer
The 3rd ASIAN CONGRESS ON SCHIZOPHRENIA RESEARCH(ACSR2013)
Place of Presentation
Sanur, Bali, Indonesia
Year and Date
20130214-16
