Study on the improvement of neural network disruption in depression.

2013 Fiscal Year Final Research Report

• Project/Area Number: 23591677
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Multi-year Fund
• Section: 一般
• Research Field: Psychiatric science
• Research Institution: Sapporo Medical University
• Principal Investigator: HASHIMOTO Eri 札幌医科大学, 医学部, 准教授 (30301401)
• Co-Investigator(Kenkyū-buntansha): UKAI Wataru 札幌医科大学, 医学部, 講師 (40381256) ; YAMADA Misa 独立行政法人国立精神・神経研究センター, 精神保健研究所, 研究員 (10384182)
• Project Period (FY): 2011 – 2013
• Keywords: 神経科学 / 脳・神経 / うつ病 / 抗うつ薬 / 神経新生

Research Abstract

We evaluated the effective treatment way of cellular biodistribution of stem cells and BDNF into the brain after intravenous injection. We analyzed the influence of antidepressants on platelet BDNF release and found that BDNF release from platelets may be useful for screening the most suitable antidepressant by predicting an individual response to antidepressant treatment. We also investigated the expression of rhotekin and Prg1 in adult rat brain and found that they may play important roles in neurogenesis.

Research Products

• [Journal Article] Plasticity-related gene 1 is important for survival of neurons derived from rat neural stem cells. (2013)
  • Author(s): Hashimoto T, Yamada M, Imai T, Saitoh A, Hashimoto E, Ukai W, Saito T, Yamada M.
  • Journal Title: J Neurosci Res Volume: 91 Pages: 1402-1407
  • DOI: DOI: 10.1002/jnr.23269.
  • Peer Reviewed
• [Journal Article] Effects of atelocallagen on neural stem function and its migrating capacity into brain in psychiatric disease model. (2013)
  • Author(s): Yoshinaga T, Hashimoto E, Ukai W, Ishii T, Shirasaka T, Kigawa Y, Tateno M, Kaneta H, Watanabe K, Igarashi T, obayashi S, Sohma H, Kato T, Saito T.
  • Journal Title: J Neural Transm Volume: 120 Pages: 1491-1498
  • DOI: DOI: 10.1007/s00702-013-1010-4.
  • Peer Reviewed
• [Journal Article] Rhotekin modulates differentiation of cultured neural stem cells to neurons. (2012)
  • Author(s): Iwai T, Saitoh A, Yamada M, Takahashi K, Hashimoto E, Ukai W, Saito T, Yamada M.
  • Journal Title: J Neurosci Res Volume: 90 Pages: 1359-1366
  • DOI: DOI: 10.1002/jnr. 23029.
  • Peer Reviewed
• [Presentation] Effects of ethanol and antidepressant on the platelet BDNF release function in the peripheral blood : Implication in the pathogeness of psychiatric disease. (2013)
  • Author(s): Saito T, Hashimoto E, Ukai W, Ishii T, Kigawa Y, Furuse K, Tsujino H, Kobayashi S, Yoshinaga T.
  • Organizer: 52^<nd> Annual Meeting of the American College of Neuropsychopharmacology
  • Place of Presentation: Florida, U.S.A.
  • Year and Date: 20131208-12
• [Presentation] Alteration of platelet BDNF release function in the peripheral blood. (2013)
  • Author(s): Saito T, Hashimoto E, Ukai W, Ishii T, Kigawa Y, Furuse K, Tsujino H, Kobayashi S, Yoshinaga T.
  • Organizer: The 3^<rd> Congress of Asian Colloge of Neuropsychopharmacology
  • Place of Presentation: Beijing, China.
  • Year and Date: 20130911-14
• [Presentation] Basic aspects of alcohol use disorder comorbid with depressive disorder. (2013)
  • Author(s): Hashimoto E, Ukai W, Ishii T, Kigawa Y, Yoshinaga T, Watanabe K, Shirasaka T, Tateno M, Kobayashi S, Saito T.
  • Organizer: [Symposium] Alcohol abuse comorbidity. 14^<th> Congress of ESBRA
  • Place of Presentation: Warsaw, Poland.
  • Year and Date: 20130908-11
• [Presentation] Usage of peripheral-derived cytokine as a marker and treatment approach for neural plasticity change in alcohol-induced brain damage and depression. (2013)
  • Author(s): Hashimoto E, Ukai W, Ishii T, Watanabe K, Shirasaka T, Kaneta H, Kigawa Y, Yoshinaga T, Tateno M, Saito T.
  • Organizer: [Symposium] Trans- lational perspective on the imaging, epigenetics and peripheral-derived markers for alcohol induced brain damage and depression. 11^<th> World Congress of Biological Psychiatry
  • Place of Presentation: Kyoto, Japan.
  • Year and Date: 20130623-27
• [Presentation] intravenous therapy for psychiatric diseases : regeneration of damaged neural network by ethanol and depression. (2012)
  • Author(s): Ukai W, Hashimoto E, Shirasaka T, Kaneta H, Igarashi T, Kigawa M, Watanabe K, Yoshinaga T, Tateno M, Ishii T, Saito T.
  • Organizer: 35^<th> Annual Scientific Meeting for Research on Alcoholism
  • Place of Presentation: San Francisco, U.S.A.
  • Year and Date: 20120623-27
• [Book] 気分障害の薬理・生化学～うつ病の脳内メカニズム研究 : 進歩と挑戦～ (2012)
  • Author(s): 橋本恵理
  • Total Pages: 153-155
  • Publisher: 医薬ジャーナル社