2013 Fiscal Year Final Research Report
Social function reovery in schizophrenia: can combined therapy with drug and cells repair neural circuit of verbal memory and sympathy/empathy?
| Project/Area Number |
23591679
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Psychiatric science
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| Research Institution | Sapporo Medical University |
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Principal Investigator |
UKAI Wataru 札幌医科大学, 医学部, 講師 (40381256)
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| Co-Investigator(Kenkyū-buntansha) |
HASHIMOTO Eri 札幌医科大学, 医学部, 准教授 (30301401)
TATENO Masaru 札幌医科大学, 医学部, 講師 (60464492)
YOSHINAGA Toshihiro 札幌医科大学, 医学部, 助教 (70404704)
KANETA Hiroo 札幌医科大学, 医学部, 研究員 (80581149)
ATAKA Koji 札幌医科大学, 医学部, 講師 (30563358)
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| Project Period (FY) |
2011 – 2013
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| Keywords | 精神薬理学 / 統合失調症 / 認知機能 / 神経再生 / 神経新生 / 細胞移植 / 再生医療 / 神経分化 |
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| Research Abstract |
The purpose of this study is to investigate the influence of antipsychotic on the neural circuit of verbal memory and theory of mind which has high impact on working and social function recoveries in schizophrenic patients and to link it to the development of the new regenerative strategy for psychiatric disease treatment. In the experiments using neural/glial stem cells derived from adult brain, it was revealed that all the tested atypical antipsychotics promoted NG2(+) cell differentiation to GABAergic interneuron inhibited by MK-801. As one of the candidate molecular mechanisms of this GABAergic interneurgenesis promotion by antipsychotics, we have indicated the involvement of HSP 90 expression change. These results suggested that the increase of adult GABAergic interneurogenesis through HSP90 expression change might be involved in the mechanisms of neural network repair in the schizophrenic brain and cognitive function recoveries by the atypical antipsychotic treatments.
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[Journal Article] Effects of atelocollagen on neural stem cell function and its migrating capacity into brain in psychiatric disease model2013
Author(s)
Yoshinaga T, Hashimoto E, Ukai W, Ishii T, Shirasaka T, Kigawa Y, Tateno M, Kaneta H, Watanabe K, Igarashi T, Kobayashi S, Sohma H, Kato T, Saito T
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Journal Title
J Neural Transm
Volume: 120
Pages: 1491-1498
DOI
Peer Reviewed
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[Journal Article] 統合失調症の脳神経回路修復薬物・細胞コンバインド療法の可能性の検討2012
Author(s)
鵜飼渉,小野貴文,橋本恵理,金田博雄,白坂知彦,五十嵐健史,木川昌康,渡邊公彦,吉永敏弘,石井貴男,館農勝,小林清樹,齋藤利和
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Journal Title
日本生物学的精神医学会誌
Volume: 23
Pages: 109-114
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[Journal Article] Heat stress activates ER stress signals which suppress the heat shock response, an effect occurring preferentially in the cortex in rats2012
Author(s)
Liu Y, Sakamoto H, Adachi M, Zhao S, Ukai W, Hashimoto E, Hareyama M, Ishida T, Imai K, Shinomura Y
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Journal Title
Mol Biol Rep
Volume: 39
Pages: 3987-3993
DOI
Peer Reviewed
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[Presentation] Atypical antipsychotics promote GABA interneurogenesis in the adult brain : implication of HSP production2013
Author(s)
Ukai W, Kaneta H, Kigawa Y, Hashimoto E, Ishii T, Furuse K, Kakutani Y, Imai T, Tsujino H, Kobayashi S, Saito T
Organizer
43nd Annual Meeting of The Society for Neuroscience (SfN)
Place of Presentation
San Diego, California
Year and Date
20131109-13
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[Presentation] 統合失調症の成体脳神経産生機構に対する薬物・細胞投与の影響に関する研究2013
Author(s)
鵜飼渉,金田博雄,橋本恵理,木川昌康,白坂知彦,石井貴男,今井智之,小林清樹,吉永敏弘,館農勝,齋藤利和
Organizer
第8回日本統合失調症学会
Place of Presentation
浦河 (シンポジウム)
Year and Date
20130419-20
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[Presentation] The effect of antipsychotics on GABAergic interneurogenesis in adult brain2012
Author(s)
Ukai W, Kaneta H, Hashimoto E, Igarashi T, Kigawa Y, Shirasaka T, Watanabe K, Yoshinaga T, Tateno M, Ishii T, Saito T
Organizer
28th Collegium Internationale Neuro-Psychopharmacologicum (CINP) Congress
Place of Presentation
Stockholm, Sweden
Year and Date
20120603-07
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[Presentation] Cell-based therapy for alcohol-induce brain damage2012
Author(s)
Ukai W, Shirasaka T, Hashimoto E, Kaneta H, Igarashi T, Watanabe k, Yoshinaga T, Tateno M, Ishii T, Saito T
Organizer
The 2nd Congress of Asia-Pacific Society for Alcohol and Addiction Research (APSAAR)
Place of Presentation
Bangkok (Symposium)
Year and Date
20120206-08
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[Presentation] The effect of antipsychotics in interneurogenesis of adult neural stem cells2011
Author(s)
Kaneta H, Ukai W, Hashimoto E, Yoshinaga T, Tateno M, Watanabe K, Shirasaka T, Igarashi T, Ishii T, Saito T
Organizer
The 41st annual meeting of the Society of Neuroscience
Place of Presentation
Washington, D.C., U.S.A.
Year and Date
20111112-16
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[Presentation] Promotion of interneurogenesis by neural stem cell transplantation in FASD model2011
Author(s)
Ukai W, Shirasaka T, Hashimoto E, Yoshinaga T, Kaneta H, Kigawa Y, Igarashi T,Watanabe K, Tateno M, Ishii T, Saito T
Organizer
13th Congress of European Society for Biomedical Research on Alcoholism
Place of Presentation
Vienna, Austria
Year and Date
20110904-07
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