2013 Fiscal Year Final Research Report
Brain imaging and apolipoprotein E phenotypes in argyrophilic grain dementia
| Project/Area Number |
23591692
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Psychiatric science
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| Research Institution | Yamagata University |
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Principal Investigator |
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| Co-Investigator(Renkei-kenkyūsha) |
HAYASHI Hiroshi 山形大学, 医学部, 講師 (00333956)
SHIBUYA Yuzuru 山形大学, 医学部, 助教 (80400555)
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| Project Period (FY) |
2011 – 2013
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| Keywords | 嗜銀顆粒性認知症 / 磁気共鳴画像 / 海馬 / アルツハイマー型認知症 / アポリポ蛋白E |
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| Research Abstract |
Using the anterior medial temporal lobe atrophy on conventional axial MRI as a marker for argyrophilic grain dementia (AGD), we clinically identified patients with AGD. We performed voxel-based morphometry (VSRAD advance using SPM8 and DARTEL) and examined apolipoprotein E (ApoE) phenotypes in 100 patients with AGD and 100 patients AD to clarify the morphological and genetic features of AGD. VSRAD revealed the AGD group had significantly higher Z-scores, reflecting the medial temporal lobe atrophy, than the AD group. The rate of ApoE4 carrier was significantly lower in AGD group than in AD group (31% vs 59%), suggesting that ApoE4 has less impact on AGD compared to AD.
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