A prospective study of the pathogenesis of Premenstrual Mood Disorder

2016 Fiscal Year Final Research Report

• Project/Area Number: 23591702
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Multi-year Fund
• Section: 一般
• Research Field: Psychiatric science
• Research Institution: Mie University
• Principal Investigator: OKANO TADAHARU 三重大学, 保健管理センター, 教授 (90169128)
• Project Period (FY): 2011-04-28 – 2017-03-31
• Keywords: 月経前気分不快障害 / 分娩 / 好発時期 / 危険因子 / マタニティー・ブルーズ

Outline of Final Research Achievements

Objective:　The aim of this study is to examine the prevalence of PMS and PMDD after delivery.　Methods: A longitudinal survey was done at Mie University Hospital. Of 218 subjects approached, 200 pregnant women were finally analyzed for sociodemographic data, menstrual history, and premenstrual symptoms. Results: The prevalence of PMDD was 7.3 % (9/124) and moderate to severe PMS was 8.1% at one year after delivery. Only two of PMDD women had previous histories of PMDD episode.　Women with PMMD group showed significantly higher HADS-A scores and HADS-D scores and EPDS scores.　Women with histories of PMS group showed significantly higher Stein’s scores and EPDS scores in 5th day postpartum. Conclusions: Prevalence rate of PMDD at one year after delivery is similar to other studies from Western countries. Most of the instances of PMDD were the first episode after delivery. There must be some mechanism suggested for the first onset of PMDD according to the change of hormonal mechanism.

Free Research Field

内科系臨床医学・精神神経科学