The establishment of clinical index and biomarker for confabulation and delusion in dementia.

2013 Fiscal Year Final Research Report

• Project/Area Number: 23591711
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Multi-year Fund
• Section: 一般
• Research Field: Psychiatric science
• Research Institution: Ehime University
• Principal Investigator: TANIMUKAI Satoshiu 愛媛大学, 医学(系)研究科(研究院), 准教授 (90361336)
• Co-Investigator(Kenkyū-buntansha): MATYSUMOTO Teruhisa 愛媛大学, 医学部附属病院, 助教 (20581094) ; FUKUHARA Ryuji 愛媛大学, 医学部附属病院, 講師 (60346682)
• Project Period (FY): 2011 – 2013
• Keywords: 認知症 / 作話 / 取り繕い / 妄想 / ビタミンB1 / 葉酸

Research Abstract

Many demented people answer " No" , if we ask them, " Do you take a nap ?" . But all the demented people who answer "Yes" to the same question, did not showed confabulation symptom in our study. Confabulation is not present, when the patient and family were made same evaluation about the patient's sleeping condition. In the Geriatric Depression Scale (GDS), Their score tends to be low towards the confabulation syomapom. There was no corrilation with conafabulation symptom, between serum vitamin B1, vitamin B12 and foric acid. In patients, who occurred conafaburation symptom during the observation period, their GDS score has been reduced. And the showed, low serum level of vitamin B12 at the intial visit.

Research Products

• [Journal Article] Apathy correlates with prefrontal amyloid beta deposition in Alzheimer's disease (2014)
  • Author(s): Mori T, Shimada H, Shinotoh H, Hirano S, Eguchi Y, Yamada M, Fukuhara R, Tanimukai S, Kuwabara S, Ueno S, Suhara T
  • Journal Title: J Neurol Neurosurg Psychiatry Volume: 85 Pages: 449-455
  • Peer Reviewed
• [Journal Article] 多彩な神経症状を呈し,遺伝子診断によりAPP遺伝子変異を認めた若年Alzheimer病の1例 (2013)
  • Author(s): 石丸喬士,越智紳一郎,松本光央,吉田卓,安部賢郎,豊田泰孝,福原竜治,谷向知,上野修一
  • Journal Title: 精神神経医学雑誌 Volume: 115 Pages: 1042-1050
  • Peer Reviewed
• [Journal Article] Association between cognitive function and plasma lipids of the elderly after controlling for apolipoprotein E genotype (2012)
  • Author(s): Yasuno F, Tanimukai S, Sasaki M, Hidaka S, Ikejima C, Yamashita F, Kodama C, Mizukami K, Michikawa M, Asada T
  • Journal Title: Am J Geriatr Psychiatry Volume: 20 Pages: 574-583
  • Peer Reviewed
• [Journal Article] Clinical profiles of late-onset semantic dementia, compared with early-onset semantic dementia and late-onset Alzheimer's disease (2011)
  • Author(s): Shimizu H, Komori K, Fukuhara R, Shinagawa S, Toyota Y, Kashibayashi T, Sonobe N, Matsumoto T, Mori T, Ishikawa T, Hokoishi K, Tanimukai S, Ueno S, Ikeda M
  • Journal Title: Psychogeriatrics Volume: 11 Pages: 46-53
  • Peer Reviewed
• [Presentation] レビー小体型認知症における脳血流と精神症状の関係 (2013)
  • Author(s): 吉田卓,森崇明,園部直美,清水秀明,松本光央,谷向知,上野修一
  • Organizer: 第28回日本老年精神医学会
  • Place of Presentation: 大阪国際会議場
  • Year and Date: 20130604-06
• [Presentation] 4年の経過で正常圧水頭症の画像を呈したアルツハイマー型認知症の1例 (2011)
  • Author(s): 瀬野隆太, 福原竜治, 森崇明, 松本光央, 豊田泰孝, 園部直美, 清水秀明, 坂根真弓, 吉田卓, 森蓉子, 谷向知
  • Organizer: 第26回日本老年精神医学会
  • Place of Presentation: 京王プラザホテル
  • Year and Date: 20110615-17
• [Book] 認知症によるコミュニケーションの障害に対する評価のポイント、^<なし>言語療法の組み立て方や技法について教えてください.失語症Q&A (2013)
  • Author(s): 小森憲治郎,谷向知 (種村純編)
  • Total Pages: 176-179
  • Publisher: 新興医学出版社,東京
• [Book] 「脳とこころのプライマリケア2知能の衰え」,専門医との連携 (2013)
  • Author(s): 谷向知 (池田学編)
  • Total Pages: 509-515
  • Publisher: シナジー,東京
• [Book] 認知症介護における介護者支援のための課題介護うつ.老年社会科学(34) (2013)
  • Author(s): 谷向知,坂根真弓,酒井ミサヲ,吉田卓,藤田君子,豊田泰孝,小森憲治郎
  • Total Pages: 511-515
• [Book] 認知症をきたす主要疾患―特徴的な臨床像と診断基準―前頭側頭葉変性症Medical (29)Practice (2012)
  • Author(s): 谷向知
  • Total Pages: 757-765
• [Book] 認知症の人の生活を知る帰宅願望ともの盗られ妄想.クリニシアン(59) (2012)
  • Author(s): 谷向知
  • Total Pages: 357-362
• [Book] 「脳とこころのプライマリケア6幻覚と妄想」, Korsakoff症候群 (2011)
  • Author(s): 樫林哲雄, 福原竜治, 清水秀明, 谷向知 (堀口淳編)
  • Total Pages: 379-384
  • Publisher: シナジー, 東京