2013 Fiscal Year Final Research Report
neural basis of derangement of ego in schizophrenia
| Project/Area Number |
23591712
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Psychiatric science
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| Research Institution | Kyushu University |
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Principal Investigator |
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| Project Period (FY) |
2011 – 2013
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| Keywords | 統合失調症 / 脳磁図 / ＭＲＩ / 自我障害 |
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| Research Abstract |
The current study investigated the visually evoked oscillations for subject's family name using magnetoencephalography (MEG). Twenty SZ patients and 20 normal controls (NC) participated in this study. The MEG signals were acquired using a whole-head, 306-channel sensor array. In this study, we presented visually four types of Japanese character string (kana): (1) subject's family name (30%), (2) another family name (30%), (3) meaningless string (30%), (4) a Japanese city name (target, 10%). In the mean power of evoked high gamma oscillations between 190msec and 210msec after stimulus onset, a repeated measures ANOVA demonstrated significant stimulus-by-group interactions. In post-hoc analyses, NC showed a significant difference (subject's family name>another family name>meaning less string), but there was no significant stimulus effect in SZ. The high gamma frequency neural oscillatory abnormalities of SZ may indicate a new evidence for neural basis of derangement of ego.
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