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2013 Fiscal Year Final Research Report

Neural correlate of abnormal eating behavior in semantic dementia

Research Project

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Project/Area Number 23591718
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeMulti-year Fund
Section一般
Research Field Psychiatric science
Research InstitutionKumamoto University

Principal Investigator

IKEDA Manabu  熊本大学, 大学院生命科学研究部, 教授 (60284395)

Co-Investigator(Kenkyū-buntansha) HASHIMOTO Mamoru  熊本大学, 医学部附属病院, 講師 (20452881)
HIRAI Toshinori  熊本大学, 大学院生命科学研究部, 准教授 (40274724)
Project Period (FY) 2011 – 2013
Keywords老年精神医学 / 神経回路
Research Abstract

As is well known, patients with frontotemporal lobar degeneration (FTLD) show various abnormal eating behaviors. However there are few researches focused on eating behavior in semantic dementia (SD) that is a clinical subtype of FTLD. Subjects were 19 SD patients, in which assessment scale of eating behaviors and brain SPECT were undergone. The assessment scale consists of 5 domains: swallowing problem, appetite change, food preference, eating habits and other oral behaviors. Semi-quantitative methods were used to assess rCBF changes. Regional tracer uptake was measured in region of interest (ROI) over the bilateral superior and inferior frontal cortex, lateral and medial temporal cortex, thalamus and cerebellum, and calculated ROI ratios divided by ROI in cerebellum. Using partial correlation analysis adjusted by duration of illness showed significant correlations between right frontal cortex and increased appetite, and between bilateral temporal cortex and changes of food preference.

  • Research Products

    (23 results)

All 2014 2013 Other

All Journal Article (9 results) (of which Peer Reviewed: 9 results) Presentation (7 results) Book (7 results)

  • [Journal Article] Multicenter population-based study on the prevalence of early onset dementia in Japan : Vascular dementia as its prominent cause2014

    • Author(s)
      Ikejima C, Ikeda M, Hashimoto M, Ogawa Y, Tanimukai S, Kashibayashi T, Miyanaga K, Yonemura K, Kakuma T, Murotani K, Asada T
    • Journal Title

      Psychiatry and Clinical Neurosciences

      Volume: 68 Pages: 216-224

    • Peer Reviewed
  • [Journal Article] on behalf of the Donepezil-DLB Study Investigators. Long-term safety and efficacy of Donepezil in patients with dementia with Lewy Bodies : Results from a 52-week, open-label, multicenter extension study2013

    • Author(s)
      Ikeda M, Mori E, Kosaka K, Iseki E, Hashimoto M, Matsukawa N, Matsuo K, Nakagawa M
    • Journal Title

      Dement Geriatr Cogn Disord

      Volume: 36(3-4) Pages: 229-241

    • Peer Reviewed
  • [Journal Article] Efficacy of increasing donepezil in mild to moderate Alzheimer's disease patients who show a diminished response to 5 mg donepezil : a preliminary study2013

    • Author(s)
      Yatabe Y, Hashimoto M, Kaneda K, Honda K, Ogawa Y, Yuki S, Ikeda M
    • Journal Title

      Psychogeriatrics

      Volume: 13(2) Pages: 88-93

    • Peer Reviewed
  • [Journal Article] Prevalence of delirium among outpatients with dementia2013

    • Author(s)
      Hasegawa N, Hashimoto M, Yuki S, Honda K, Yatabe Y, Araki K, Ikeda M
    • Journal Title

      Int Psychogeriatr

      Volume: 25(11) Pages: 1877-1883

    • Peer Reviewed
  • [Journal Article] The relationship between primary progressive aphasia and neurodegenerative dementia2013

    • Author(s)
      Ichimi N, Hashimoto M, Matsushita M, Yano H, Yatabe Y, Ikeda M
    • Journal Title

      East Asian Arch Psychiatry

      Volume: 23(3) Pages: 120-125

    • Peer Reviewed
  • [Journal Article] Comparison of the utility of everyday memory test and the Alzheimer's Disease Assessment Scale-Cognitive part for evaluation of mild cognitive impairment and very mild Alzheimer's disease2013

    • Author(s)
      Adachi H, Ikeda M, Komori K, Shinagawa S, Toyota Y, Kashibayashi T, Ishikawa T, Tachibana N
    • Journal Title

      Psychiatry Clin Neurosci

      Volume: 67(3) Pages: 148-153

    • Peer Reviewed
  • [Journal Article] The usefulness of monitoring sleep talking for the diagnosis of dementia with Lewy bodies2013

    • Author(s)
      Honda K, Hashimoto M, Yatabe Y, Kaneda K, Yuki S, Ogawa Y, Matsuzaki S, Tsuyuguchi A, Tanaka H, Kashiwagi H, Hasegawa N, Ishikawa T, Ikeda M
    • Journal Title

      Int Psychogeriatrics

      Volume: 25 Pages: 851-858

    • Peer Reviewed
  • [Journal Article] Patient-related factors associated with depressive state in caregivers of patients with dementia

    • Author(s)
      Hasegawa N, Hashimoto M, Koyama A, Ishikawa T, Yatabe Y, Honda K, Yuki S, Araki K, Ikeda M
    • Journal Title

      JAMDA

      Volume: (in press)

    • Peer Reviewed
  • [Journal Article] Is sense of coherence helpful in coping with caregiver burden for dementia?

    • Author(s)
      Matsushita M, Ishikawa T, Koyama A, Hasegawa N, Ichimi N, Yano H, Hashimoto M, Fujii N, Ikeda M
    • Journal Title

      Psychogeriatrics

      Volume: (in press)

    • Peer Reviewed
  • [Presentation] ASAD Joint Symposium on Dementia : Frontotemporal Dementia in Asia2014

    • Author(s)
      Ikeda M
    • Organizer
      14th Asian & Oceanian Congress of Neurology
    • Place of Presentation
      The Venetian Macao, Macao, China
    • Year and Date
      20140302-05
  • [Presentation] Keynote address : Overview on the diagnosis and management of frontotemporal lobar degeneration2014

    • Author(s)
      Ikeda M
    • Organizer
      9th Annual Meeting of Taiwanese Society of Geriatric Psychiatry
    • Place of Presentation
      Chung Shan Medical University, Taichung city, Taiwan
    • Year and Date
      2014-03-16
  • [Presentation] 認知症の病態と治療薬の動向(シンポジウム)「レビー小体型認知症と前頭側頭葉変性症の病態と治療」2013

    • Author(s)
      池田学
    • Organizer
      第23回日本臨床精神神経薬理学会・第43回日本神経精神薬理学会合同年会
    • Place of Presentation
      沖縄県宜野湾市
    • Year and Date
      20131024-26
  • [Presentation] Symposium : Dementia care. Community outreach services for dementia : Basic requirements2013

    • Author(s)
      Ikeda M
    • Organizer
      7th Congress of Asian Society Against Dementia
    • Place of Presentation
      Cebu city, Philippines
    • Year and Date
      20131009-12
  • [Presentation] Symposium : Frontotemporal lobar degeneration in Asia. FTLD in Asia–overview2013

    • Author(s)
      Ikeda M
    • Organizer
      International Psychiatric Association 16^<th> International Congress
    • Place of Presentation
      Seoul, Korea
    • Year and Date
      20131001-04
  • [Presentation] 若年性認知症を地域で支えるために2013

    • Author(s)
      池田学
    • Organizer
      第16回日本老年行動科学会
    • Place of Presentation
      愛媛県松山市 (基調講演)
    • Year and Date
      2013-08-31
  • [Presentation] 褥瘡の危険因子を作らないための取り組み.(シンポジウム)「認知症の予防について」2013

    • Author(s)
      池田学
    • Organizer
      第15回日本褥瘡学会学術集会
    • Place of Presentation
      兵庫県神戸市 (発表19日)
    • Year and Date
      2013-07-19
  • [Book] 前頭側頭葉変性症(含:進行性失語症).第4版わかりやすい内科学2014

    • Author(s)
      池田学 (井村裕夫編)
    • Total Pages
      600-601
    • Publisher
      文光堂,東京
  • [Book] 脳の理解.認知症予防専門士テキストブック2013

    • Author(s)
      池田学 (浦上克哉,川瀬康裕,児玉直樹編)
    • Total Pages
      12-16
    • Publisher
      徳間書店,東京
  • [Book] 前頭側頭型認知症.神経・精神疾患診療マニュアル2013

    • Author(s)
      池田学 (北川泰久,寺本明,三村將編)
    • Total Pages
      199-200
    • Publisher
      日本医師会,東京
  • [Book] 認知症.脳血管障害と神経心理学第2版2013

    • Author(s)
      池田学 (平山恵造,田川皓一編)
    • Total Pages
      77-82
    • Publisher
      医学書院,東京
  • [Book] 認知症とケア.脳とこころのプライマリケア2知能の衰え2013

    • Author(s)
      池田学,小松優子 (池田学編集)
    • Total Pages
      51-56
    • Publisher
      シナジー,東京
  • [Book] 改訂阪老年病・認知症〜長寿の秘訣〜2013

    • Author(s)
      池田学 (荻原俊男監修)
    • Publisher
      メディカルレビュー社,東京
  • [Book] 梅毒.誤診症例から学ぶ認知症とその他の疾患の鑑別2013

    • Author(s)
      松崎志保,橋本衛,池田学
    • Total Pages
      156-167
    • Publisher
      医学書院,東京

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Published: 2015-07-16  

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