Study for FKBP5 and CRHR1 in depression and panic disorder

2013 Fiscal Year Final Research Report

• Project/Area Number: 23591719
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Multi-year Fund
• Section: 一般
• Research Field: Psychiatric science
• Research Institution: Oita University
• Principal Investigator: AKIYOSHI Jotaro 大分大学, 医学部, 准教授 (00159344)
• Co-Investigator(Kenkyū-buntansha): TANAKA Yoshihiro 大分大学, 医学部, 助教 (60516102) ; ISHITOBI Yoshinobu 大分大学, 医学部, 助教 (40516118) ; KOHNO Kentaro 大分大学, 医学部, 医員 (30555181) ; IMANAGA Junko 大分大学, 医学部, 医員 (30583504) ; INOUE Ayako 大分大学, 医学部, 医員 (10630949) ; ANDO Tomoko 大分大学, 医学部, 臨床心理士 (80516120) ; KAWANO Aimi 大分大学, 医学部, 臨床心理士 (80583492)
• Project Period (FY): 2011 – 2013
• Keywords: FKBP5 / CRHR1 / ストレス / 唾液アミラーゼ / 唾液コルチゾール

Research Abstract

CRHR1 and FKBP5 gene were also found an association with depression and panic disorder. These genetic polymorphisms were found to be associated with anxiety. The context of FKBP5 gene polymorphism was significantly related to the VBM of frontal lobe and amygdala. CRHR1 genes and FKBP5 related to the stress were associated with depression and panic disorder. Our results showed that a significant interaction exists between FKBP5 SNPs, salivary cortisol and salivary amylase responses at three levels of regulation. Salivary cortisol and amylase responses were significantly associated with FKBP5. The brain volume could be also affected by these genes.

Research Products

• [Journal Article] Association between corticotropin-releasing hormone receptor 1 and 2 (CRHR1 and CRHR2) gene polymorphisms and personality traits (2013)
  • Author(s): Ishitobi Y, Nakayama S, Kanehisa M, Higuma H, Maruyama Y, Okamoto S, Inoue A, Imanaga J, Tanaka Y, Tsuru J, Hanada H, Akiyoshi J
  • Journal Title: Psychiatr Genet Volume: 23(6) Pages: 255-7
  • DOI: 10.1097/YPG.0000000000000002
  • Peer Reviewed
• [Journal Article] Salivary alpha-amylase and cortisol responsiveness following electrical stimulation stress in patients with the generalized type of social anxiety disorder (2013)
  • Author(s): Tamura A, Maruyama Y, Ishitobi Y, Kawano A, Ando T, Ikeda R, Inoue A, Imanaga J, Okamoto S, Kanehisa M, Ninomiya T, Tanaka Y, Tsuru J, Akiyoshi J
  • Journal Title: Pharmacopsychiatry Volume: 46(7) Pages: 225-60
  • DOI: 10.1055/s-0033-1353157
  • Peer Reviewed
• [Journal Article] The thyrotropin-releasing hormone test may predict recurrence of clinical depression within ten years after discharge (2013)
  • Author(s): Tsuru J, Ishitobi Y, Ninomiya T, Kanehisa M, Imanaga J, Inoue A, Okamoto S, Maruyama Y, Higuma H, Tanaka Y, Hanada H, Isogawa K, Akiyoshi J
  • Journal Title: Neuro Endocrinol Lett Volume: 34(5) Pages: 409-17
  • Peer Reviewed
• [Journal Article] Salivary alpha-amylase and cortisol responsiveness following electrical stimulation stress in obsessive-compulsive disorder patients (2013)
  • Author(s): Kawano A, Tanaka Y, Ishitobi Y, Maruyama Y, Ando T, Inoue A, Okamoto S, Imanaga J, Kanehisa M, Higuma H, Ninomiya T, Tsuru J, Akiyoshi J
  • Journal Title: Psychiatry Res Volume: 209(1) Pages: 85-90
  • DOI: 10.1016/j.psychres.2012
  • Peer Reviewed
• [Journal Article] The value of ethyl cysteinate dimer single photon emission computed tomography in predicting antidepressant treatment response in patients with major depression (2013)
  • Author(s): Hanada H, Imanaga J, Yoshiiwa A, Yoshikawa T, Tanaka Y, Tsuru J, Inoue A, Ishitobi Y, Okamoto S, Kanehisa M, Maruyama Y, Ninomiya T, Higuma H, Isogawa K, Kawasaki T, Fujioka T, Akiyoshi J
  • Journal Title: Int J Geriatr Psychiatry Volume: 28(7) Pages: 756-65
  • DOI: 10.1002/gps.3887
  • Peer Reviewed
• [Presentation] 機能画像法によるヒト脳注意関連神経回路と遺伝多形 (2014)
  • Author(s): 山田和寛, 藤井康右, 黒木千尋, 穐吉條太郎, 河野義久
  • Organizer: 第91回日本生理学会大会
  • Place of Presentation: 鹿児島大学郡元キャンパス(鹿児島)
  • Year and Date: 20140316-18
• [Presentation] BDNF Val66Met polymorphism is associated with different HPA and SAS axis reactivity to psychological and physical stress characterized by genotype interaction (2013)
  • Author(s): Akiyoshi J, Tsuru J, Tanaka Y, Ishitobi Y, Maruyama Y, Inoue A, Kawano A, Ando T, Imanaga J, Okamoto S, Kanehisa M
  • Organizer: 21st World Congress of Psychiatric Genetics
  • Place of Presentation: Seaport Hotel & World Trade Center(アメリカ、ボストン)
  • Year and Date: 20131017-21
• [Presentation] Association between transcription of neuroplasticity-related genes and variation in stress coping-style (2013)
  • Author(s): Aizawa S, Ishitobi Y, Ando T, Kawano A, Ikeda R, Inoue A, Kanehisa M, Higuma H, Ninomiya T, Maruyama Y, Okamoto S, Imanaga J, Tsuru J, Tanaka Y, Akiyoshi J
  • Organizer: 21st World Congress of Psychiatric Genetics
  • Place of Presentation: Seaport Hotel & World Trade Center(アメリカ、ボストン)
  • Year and Date: 20131017-21
• [Presentation] BDNF Val66Met polymorphism is associated with different HPA and SAS axis reactivity to psychological and physical stress characterized by genotype interaction (2013)
  • Author(s): Akiyoshi J, Tsuru J, Tanaka Y, Ishitobi Y, Maruyama Y, Kawano A, Ando T, Inoue A, Imanaga J, Okamoto S, Kanehisa M
  • Organizer: 11th World Congress of Biological Psychiatry
  • Place of Presentation: 国立京都国際会館(京都)
  • Year and Date: 20130623-27
• [Presentation] The catechol-O-methultransferase gene (COMT), other gene polymorphism and congnitive function (2013)
  • Author(s): Ishitobi Y, Tanaka Y, Maruyama Y, Kawano A, Ando T, Inoue A, Okamoto S, Imanaga J, Kanehisa M, Higuma H, Ninomiya T, Tsuru J, Akiyoshi J
  • Organizer: 11th World Congress of Biological Psychiatry
  • Place of Presentation: 国立京都国際会館(京都)
  • Year and Date: 20130623-27