2013 Fiscal Year Final Research Report
A study on autonomic nervous system activities during sleep and the prognosis of major depression
| Project/Area Number |
23591726
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Psychiatric science
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| Research Institution | Kitasato University |
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Principal Investigator |
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| Co-Investigator(Kenkyū-buntansha) |
TAGAYA Hirokuni 北里大学, 医療衛生学部, 教授 (50342928)
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| Project Period (FY) |
2011 – 2013
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| Keywords | うつ病 / 自律神経 / 予後 |
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| Research Abstract |
Previous studies have shown that incidence of depression or its severity is associated with autonomic nerves system activities. But no study on autonomic nerves system activities as a marker for prognosis of depression has been performed yet. This study aims to examine to what extent changes in the autonomic nervous system during sleep in the early treatment can predict the prognosis of depression treatment, by using major depression patients who meet DSM-4 diagnostic criteria and by measuring autonomic nervous system activities during their sleep. In the antidepressant efficacy cases, it was speculated that parasympathetic components during sleep may improve from the early stage, but this study shows a tendency that parasympathetic component during sleep is inhibited.
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