relationships between diurnal melatonin secretion profile and sleep variables in patients emergently admitted to the coronary care unit

2014 Fiscal Year Final Research Report

• Project/Area Number: 23591731
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Multi-year Fund
• Section: 一般
• Research Field: Psychiatric science
• Research Institution: Tokyo Medical University
• Principal Investigator: TAKAESU Yoshikazu 東京医科大学, 医学部, 講師 (90421015)
• Co-Investigator(Renkei-kenkyūsha): INOUE Yuichi 公益財団法人神経研究所, 研究部, センター長 (50213179) ; KOMADA Yoko 東京医科大学, 医学部, 准教授 (40451380)
• Project Period (FY): 2011-04-28 – 2015-03-31
• Keywords: メラトニン / 不眠 / 睡眠障害 / 集中治療室 / 心疾患

Outline of Final Research Achievements

To clarify the significance of melatonin secretion under intensive care conditions, we investigated melatonin secretion profiles and sleep parameters of 23 patients just after admission to the coronary care unit (CCU) and 19 age-matched controls. Sleep parameters were evaluated by actigraphy, and melatonin secretion was assessed by measuring the urinary 6-sulphatoxy melatonin (6-SMT). 6-SMT secretion was lower and nocturnal sleep parameters were less satisfactory in the subjects than those in the controls, and there were positive correlations between these variables, particularly in the subject patients. The lowered melatonin secretion might be involved in the mechanism of insomnia in CCU patients.

Free Research Field

睡眠学