2013 Fiscal Year Final Research Report
An exploration for the reason about accumulation of Vitronectin in the mouse model of Tauopathy
| Project/Area Number |
23591735
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Psychiatric science
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| Research Institution | National Institute of Radiological Sciences |
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Principal Investigator |
MARUYAMA masahiro 独立行政法人放射線医学総合研究所, 分子イメージング研究センター, 主任研究員 (80396481)
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| Project Period (FY) |
2011 – 2013
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| Keywords | ビトロネクチン / タウモデルマウス / 脳萎縮 / ビトロネクチン受容体 |
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| Research Abstract |
The accumulation of vitronectin(Vn) in the perforant pathway of hippocampal area was found in PS19 tau mice. The hippocampus of PS19 mice has been known as the primary region of pathology with hyperphosphorylated tau accumulation. Interestingly, less Vn showed more hippocampal atrophy in the PS19 mice. Crossbreeding of the PS19 mice with Vn null mice confirmed the enhanced hippocampal atrophy. These findings suggest that Vn may have a protective function against the neuronal loss in PS19 mice.
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[Journal Article] Imaging of tau pathology in a tauopathy mouse model and in Alzheimer patients compared to normal controls2013
Author(s)
Maruyama M, Shimada H, Suhara T, Shinotoh H, Ji B, Maeda J, Zhang MR, Trojanowski JQ, Lee VM, Ono M, Masamoto K, Takano H, Sahara N, Iwata N, Okamura N, Furumoto S, Kudo Y, Chang Q, Saido TC, Takashima A, Lewis J, Jang MK, Aoki I, Ito H, Higuchi M
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Journal Title
Neuron
Volume: 79
Pages: 1094-108
DOI
Peer Reviewed
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[Journal Article] Comparison of the binding characteristics of [18F]THK-523 and other amyloid imaging tracers to Alzheimer's disease pathology2013
Author(s)
Harada R, Okamura N, Furumoto S, Tago T, Maruyama M, Higuchi M, Yoshikawa T, Arai H, Iwata R, Kudo Y, Yanai K
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Journal Title
Eur J Nucl Med Mol Imaging
Volume: 40
Pages: 125-32
DOI
Peer Reviewed
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