Usefulness of the 3 tesla MRI in the differential diagnosis between recurrence of glioma and non-tumoral treatment related changes including radiation necrosis.

2013 Fiscal Year Final Research Report

• Project/Area Number: 23591746
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Multi-year Fund
• Section: 一般
• Research Field: Radiation science
• Research Institution: Tohoku University
• Principal Investigator: TAKAHASHI Shoki 東北大学, 医学(系)研究科(研究院), 教授 (80148874)
• Co-Investigator(Kenkyū-buntansha): MUGIKURA Shunji 東北大学, 大学院医学系研究科, 講師 (20375017) ; MURATA Takaki 東北大学, 病院, 助教 (70390929) ; WATANABE Mika 東北大学, 病院, 准教授 (20292344)
• Co-Investigator(Renkei-kenkyūsha): KUMABE Toshihiro 北里大学, 医学部, 主任教授 (10250747)
• Project Period (FY): 2011 – 2013
• Keywords: グリオーマ / 脳腫瘍 / 放射線壊死 / MRI / 灌流画像 / 拡散強調画像

Research Abstract

We determined whether 3 tesla MRI is useful in distinguishing recurrence of glioma from post-treatment changes including radiation necrosis. MRI sequences in this study included contrast-enhanced perfusion weighted imaging (PWI), apparent diffusion coefficient (ADC), susceptibility weighted images (SWI) and MR spectroscopy (MRS). PWI with double-dosed contrast agent was robust sequence for evaluation of CBV and is useful for discrimination between recurrence of gliomas and post-treatment changes. However, bevacizumab, a newly introduced drug which reduces tumor neoangiogenesis, may underestimate CBV, leading to misdiagnose viable tumor as treatment related change. Further evaluation is needed for PWI under administration of bevacizumab. As for ADC, one of the hopeful sequences, recurrence of gliomas had a propensity to show lower ADC value than treatment related changes. SWI and MRS revealed considerable overlaps between two entities. Future quantitative analysis may be promising.

Research Products

• [Journal Article] Treatment results of glioblastoma during the last 30 years in a single institute (2013)
  • Author(s): Kumabe T, Saito R, Kanamori M, Chonan M, Mano Y, Shibahara I, Kawaguchi T, Kato H, Yamashita Y, Sonoda Y, Kawagishi J, Jokura H, Watanabe M, Katakura R, Kayama T, Tominaga T
  • Journal Title: Neurol Med Chir (Tokyo) Volume: 53(11) (Epub) Pages: 786-96
  • DOI: 10.2176/nmc.oa2013-0212
  • Peer Reviewed
• [Presentation] Imaging Challenges in the Assessment of Posttreatment Glioblastoma Multiforme (2014)
  • Author(s): Li Li, Shunji Mugikura, Takaki Murata, Yasuko Tatewaki, Daddy Mata Mbemba, Keiichi. Jingu, Shoki Takahashi
  • Organizer: European Congress of Radiology
  • Place of Presentation: Vienna, Austria
  • Year and Date: 20140306-10
• [Presentation] Imaging Manifestations of Radiation Induced Brain Injury (2013)
  • Author(s): Li Li, Shunji Mugikura, Takaki Murata, Yasuko Tatewaki, Daddy Mata Mbemba, Shoki Takahashi
  • Organizer: 99^<th> annual meeting of Radiological Society of North America
  • Place of Presentation: Chicago, United States of America
  • Year and Date: 20131201-06
• [Presentation] Radiologic Evaluation of Pseudoprogression and Pseudoresponse in Glioblastoma : What Radiologists Need to Know (2013)
  • Author(s): Geunwon Kim, Katherine M Gallagher, Nadja Kadom, Yukio Kimura, Ta kaki Murata, Naoko Saito, Akifumi Fujita, Osamu Sakai
  • Organizer: 99^<th> annual meeting of Radiological Society of North America
  • Place of Presentation: Chicago United States of America
  • Year and Date: 20131201-06
• [Presentation] 神経膠腫の磁化率強調画像と灌流画像による評価 (2013)
  • Author(s): 李麗、麦倉俊司、村田隆紀、舘脇康子、Mata Mbemba Daddy、高橋昭喜
  • Organizer: 第128回日本医学放射線学会北日本地方
  • Place of Presentation: 新潟
  • Year and Date: 2013-06-14