2013 Fiscal Year Final Research Report
The development and clinical applications for non-invasive functional imaging using Arterial Spin Labeling (ASL) on 3T-MRI
Project/Area Number |
23591757
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Research Category |
Grant-in-Aid for Scientific Research (C)
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Allocation Type | Multi-year Fund |
Section | 一般 |
Research Field |
Radiation science
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Research Institution | University of Fukui |
Principal Investigator |
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Co-Investigator(Kenkyū-buntansha) |
YAMAMOTO Tatsuya 福井大学, 医学部, 助教 (70406073)
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Project Period (FY) |
2011 – 2013
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Keywords | MR / Perfusion / MRS / CASL / 脳血管障害 |
Research Abstract |
Arterial spin labeling (ASL) is a means of non-invasive MR perfusion assessment, which can provide a quantitative value of cerebral blood flow (CBF). However, quantitative measurement of CBF with this method depends on a number of parameters including T1 of brain and arterial transit time (DELTA). Arterial transit time has most significant effect for the accuracy of CBF calculation due to the errors in the fixed parameters. In the current study, we have demonstrated the feasibility of ATT mapping with multiple PLD approach as well as delay compensated rCBF calculation. We have demonstrated, first, the feasibility of making ATT map using a two-compartment model for CBF as well as DELTA, second, the clinical utility of ATT mapping by comparison of O2-PET and CASL-ATT obtained from the same patients. Moreover, the method of arterial side CBV calculation based on ASL has been proposed and its feasibility and model was evaluated.
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[Journal Article] Detection of preclinically latent hyperperfusion due to stroke-like episodes by arterial spin-labeling perfusion MRI in MELAS patients2013
Author(s)
Masamichi Ikawa, Makoto Yoneda, Tomoko Muramatsu, Akiko Matsunaga, Tetsuya Tsujikawa, Tatsuya Yamamoto, Nobuyuki Kosaka, Kazuyuki Kinoshita, Osamu Yamamura, Tadanori Hamano, Yasunari Nakamoto, Hirohiko Kimura
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Journal Title
Mitochondrion
Volume: 13(6)
Pages: 676-680
Peer Reviewed
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[Presentation] Detection of presymptomatically latent lesions developing into stroke-like episodes by arterial spin-labeling perfusion MRI in MELAS patients2013
Author(s)
M.Ikawa, H.Kimura, T.Muramatsu, A.Matsunaga, T.Tsujikawa, T.Yamamoto, N.Kosaka, K.Kinoshita, O.Yamamura, T.Hamano, Y.Nakamoto, M.Yoneda
Organizer
The 65th Annual Meeting of American Academy of Neurology
Place of Presentation
San Diego(USA)
Year and Date
20130316-23
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[Presentation] 3T-MRIを用いたASL(Arterial Spin Labeling)法によるCEA術前後の脳血流評価2013
Author(s)
多田愛弓, 磯﨑誠, 木戸口正宗, 荒井大志, 根石拡行, 橋本智哉, 有島英孝, 小寺俊昭, 北井隆平, 木村浩彦, 菊田健一郎
Organizer
第72回日本脳神経外科学会総会
Place of Presentation
横浜市
Year and Date
2013-10-16
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[Presentation] 3T-MRIを用いたArterial spin labeling(ASL)法による定量的脳血流評価の検討2013
Author(s)
磯﨑誠, 多田愛弓, 木戸口正宗, 荒井大志, 根石拡行, 橋本智哉, 有島英孝, 小寺俊昭, 北井隆平, 木村浩彦, 菊田健一郎
Organizer
第72回日本脳神経外科学会総会
Place of Presentation
横浜市
Year and Date
2013-10-16
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[Presentation] ヘルペス脳炎における脳血流SPECTとMRI-ASLの比較2013
Author(s)
村松倫子, 井川正道, 榎本崇一, 岸谷融, 神澤朋子, 松永晶子, 山村修, 濱野忠則, 山元龍哉, 岡沢秀彦, 木村浩彦, 米田誠
Organizer
第26回福井県脳機能画像カンファレンス
Place of Presentation
福井
Year and Date
2013-03-08
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[Presentation] Cerebral blood flow measured by Continuous Arterial Spin Labeling in INPH patients2012
Author(s)
H.Neishi, R.Kitai, A.Tada, H.Arai, S.Yamada, M.Isozaki, K.Tsunetoshi, H.Arishima, T.Kodera, H.Takeuchi, H.Kimura, K.Kikuta
Organizer
The 4th Meeting of the International Society for Hydrocephalus and Cerebrospinal Fluid Disorders
Place of Presentation
Kyoto
Year and Date
2012-10-22
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[Presentation] CEA後の脳血流評価におけるASLの有用性に関する検討2012
Author(s)
多田愛弓, 磯﨑誠, 山田真輔, 荒井大志, 根石拡行, 常俊顕三, 有島英孝, 小寺俊昭, 北井隆平, 竹内浩明, 木村浩彦, 菊田健一郎
Organizer
第71回日本脳神経外科学会総会
Place of Presentation
大阪市
Year and Date
2012-10-17
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[Presentation] 正常圧水頭症患者のMRI-CASLで測定した脳血流の検討正常高齢者との比較検討2012
Author(s)
根石拡行, 北井隆平, 荒井大志, 山田真輔, 多田愛弓, 磯﨑誠, 常俊顕三, 有島英孝, 小寺俊昭, 竹内浩明, 木村浩彦, 菊田健一郎
Organizer
第71回日本脳神経外科学会総会
Place of Presentation
大阪市
Year and Date
2012-10-17
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[Presentation] 発症24時間以内の脳梗塞例におけるMRI-CASL法の使用経験2012
Author(s)
榎本崇一, 山村修, 武田朋子, 岸谷融, 白藤法道, 村松倫子, 上野亜佐子, 松永晶子, 井川正道, 濱野忠則, 米田誠, 木村浩彦
Organizer
第15回日本栓子検出と治療学会
Place of Presentation
豊中市
Year and Date
2012-10-05
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[Presentation] CASL(continuous arterial spin labeling)と拡散強調画像でミスマッチを認め、経静脈的血栓溶解療法が有効であった脳梗塞の1例2012
Author(s)
小林久人, 中地亮, 山村修, 遠藤芳徳, 村松倫子, 岸谷融, 武田朋子, 上野亜佐子, 松永晶子, 井川正道, 濱野忠則, 米田誠, 木村浩彦
Organizer
日本神経学会東海北陸地方会
Place of Presentation
名古屋市
Year and Date
2012-03-03
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