2013 Fiscal Year Final Research Report
Systematic review for imaging of dementia
| Project/Area Number |
23591760
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Radiation science
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| Research Institution | Nagoya University |
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Principal Investigator |
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| Co-Investigator(Kenkyū-buntansha) |
TERASAWA Teruhiko 藤田保健衛生大学, 医学部, 准教授 (30399597)
ITO Kengo 独立行政法人長寿医療研究センター, 独立行政法人長寿医療研究センター・その他の部局, 部長 (70184653)
KAWAI Hisashi 名古屋大学, 医学部, 助教 (50378147)
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| Project Period (FY) |
2011 – 2013
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| Keywords | 認知症 / バイオマーカー / 画像診断 |
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| Research Abstract |
To quantitatively synthesize the test performance of imaging and cerebrospinal fluid (CSF) biomarkers for diagnosis of dementia, we conducted a systematic review and meta-analysis, with particular emphasis on comparative effectiveness.
We focused on differential diagnosis of dementia with Lewy bodies (DLB) and Frontotemporal lobar dementia (FTLD). In addition, diagnosis of mild cognitive impairment (MCI) is important theme, that is, prediction of Alzheimer disease (AD) converter and differential diagnosis of whether MCI or normal subject, or MCI or AD, etc. We searched PubMed (from January 2000 until December 2013) for English language publications, and totally reviewed 27986 publications. About the diagnosis of the MCI, we evaluated the evidence of functional MRI, diffusion tensor imaging, and perfusion imaging, using MRI, which had the potential to be innovative technology.
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