2013 Fiscal Year Annual Research Report
３テスラＤＥＮＳＥ ＭＲＩによる左室壁内心筋ストレインの定量的評価
| Project/Area Number |
23591762
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| Research Institution | Mie University |
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Principal Investigator |
佐久間 肇 三重大学, 医学(系)研究科(研究院), 教授 (60205797)
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| Co-Investigator(Kenkyū-buntansha) |
北川 覚也 三重大学, 医学部附属病院, 助教 (50378353)
永田 幹紀 三重大学, 医学部附属病院, 助教 (40402028)
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| Keywords | Myocardium / Strain / Magnetic Resonance / Sweden |
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| Research Abstract |
We investigated the agreement between strain encoded (SENC) MRI and speckle-tracking echocardiography (STE) for the assessment of right ventricular (RV) strain, and determined the accuracy of feature tracking (FT) cine MRI in quantifying altered left ventricular (LV) myocardial strain in patients with acute myocardial infarction (AMI) as compared with Displacement Encoded (DENSE) MRI.
Twelve volunteers underwent SENC MRI and STE. SENC-derived septum longitudinal peak systolic strain (mid,-17.1±3.6) showed a good agreement with STE-derived strain values (-18.3±3.8), whereas SENC-derived RV free wall longitudinal peak systolic strain (mid, -22.5±2.3) tended to be slightly smaller than STE-derived one (-29.2±4.2), indicating the necessity of angle correction. These results demonstrated that SENC MRI can provide reasonably good RV longitudinal strain as compared with STE.
To compare myocardial strain by FT to those derived from DENSE, 20 patients with AMI were evaluated. Global circumferential strain showed good agreement between FT and DENSE (Pearson’s correlation coefficient 0.85, p<0.0001). For segmental circumferential strain, Pearson’s correlation coefficient was 0.61 (p<0.0001) between FT and DENSE with bias and limits of agreement of 0.02 and －0.07 to 0.11, respectively. Regional circumferential strain determined by FT in infarct segments (-0.08 ± 0.05) was significantly impaired as compared with that in remote segments (-0.15 ± 0.05, p<0.0001). FT technique allows for accurate assessment of altered regional strain in patients with MI.
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