2013 Fiscal Year Final Research Report
MRI of locally advanced esophageal cancer: response evaluation to chemoradiotherapy
| Project/Area Number |
23591773
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Radiation science
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| Research Institution | Kyushu University (2012-2013)
National Hospital Organization, Kyushu Cancer Center (2011) |
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Principal Investigator |
KIYOHISA Hiraka 九州大学, 医学(系)研究科(研究院), 研究員 (50335973)
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| Co-Investigator(Kenkyū-buntansha) |
TSURUMARU Daisuke 九州大学, 大学病院, 助教 (90419565)
HONDA Hiroshi 九州大学, 医学研究院, 教授 (90145433)
MATSUO Yoshio 九州大学, 大学病院, 助教 (50419595)
MIYASAKA Mitsutoshi 九州大学, 大学病院, 医員 (10457434)
NISHIMUTA Yusuke 九州大学, 大学病院, 医員 (10635220)
SASAKI Tomonari 九州大学, 大学病院, 講師 (10380437)
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| Project Period (FY) |
2011 – 2013
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| Keywords | 食道癌 / 放射線化学療法 / MRI |
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| Research Abstract |
In this study, we studied the image parameters to predict the therapeutic effect of radiotherapy/chemoradiotherapy for esophageal cancer. We had done research on the response evaluation using the barium swallow as a preliminary study, and the result was that the change in the percent esohpageal stenosis before and after treatment was correlated with the therapeutic response. Our main study was the response evaluation using the MRI including diffusion-weighted images. Of the 31 cases registered cases, treatment response were evaluated in 20 cases. There was no relationship between the treatment response and the MRI findings before and after treatment in the 10 cases that underwent the definitive chemoradiotherapy. Apparent diffusion coefficient (ADC) values and change of them were significantly associated with treatent response in the 10 cases that underwent preoperative chemoratiotherapy.
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