Study of non-contrast MR imaging in evaluation of rheumatoid arthritis

2013 Fiscal Year Final Research Report

• Project/Area Number: 23591776
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Multi-year Fund
• Section: 一般
• Research Field: Radiation science
• Research Institution: Nagasaki University
• Principal Investigator: UETANI Masataka 長崎大学, 医歯(薬)学総合研究科, 教授 (40176582)
• Co-Investigator(Kenkyū-buntansha): YAMAGUCHI Tetsuji 長崎大学, 大学病院, 講師 (30380893)
• Co-Investigator(Renkei-kenkyūsha): KAWAKAMI Atsushi 長崎大学, 医歯薬学研究科, 教授 (90325639)
• Project Period (FY): 2011 – 2013
• Keywords: 関節リウマチ / MRI / 手関節

Research Abstract

Noncontrast MRI is effective in identifying bone lesions(bone marrow edema and erosion) in the wrist and finger joints associated with synovitis in early-stage RA as well as contrast MRI. The combination of MRI-proven bone marrow edema with the 2010 ACR/EULAR RA classification criteria improves the diagnostic probability of RA at an early stage. In addition, MRI-proven bone marrow edema was proved to be an indicator of control of bone and joint damage at 1-year after the treatment. Noncontrast MRI is cost-effective, as it can be efficiently conducted with lower magnetic field MR units and does not require additional cost of contrast media. The knowledge obtained by this study is expected to enhance the clinical application of noncontrast MRI in the evaluation of early-stage RA.

Research Products

• [Journal Article] Ultrasonographic examination of rheumatoid arthritis patients who are free of physical synovitis: power Doppler subclinical synovitis is associated with bone erosion (2014)
  • Author(s): Kawashiri S, Suzuki T, Nakashima Y, Horai Y, Okada A, Iwamoto N, Ichinose K., Tamai M., Arima K, Nakamura H, Origuchi T, Uetani M, Aoyagi K, Eguchi K, Kawakami A
  • Journal Title: Rheumatology Volume: 53 (Oxford) Pages: 562-569
  • DOI: 10.1093/rheumatology/ket405
  • Peer Reviewed
• [Journal Article] Synovial inflammation assessed by ultrasonography correlates with MRI-proven osteitis in patients with rheumatoid arthritis (2014)
  • Author(s): Kawashiri S, Suzuki T, Nakashima Y, Horai Y, Okada A, Nishino A, Iwamoto N., Ichinose K., Arima K., Tamai M., Nakamura H, Origuchi T, Uetani M, Aoyagi K, Eguchi K, Kawakami A
  • Journal Title: Rheumatology Volume: 22 Pages: 22
  • URL: http://rheumatology.oxfordjournals.org/content/early/2014/03/22/rheumatology.keu034.long
  • Peer Reviewed
• [Journal Article] Significant improvement in MRI-proven bone edema is associated with protection from structural damage in very early RA patients managed using the tight control approach (2013)
  • Author(s): Kita J, Tamai M, Arima K, Kawashiri S, Horai Y, Iwamoto N, Okada A, Koga T, Nakashima Y, Suzuki T, Yamasaki S, Nakamura H, Origuchi T, Ida H, Aoyagi K, Uetani M, Eguchi K, Kawakami A
  • Journal Title: Modern Rheumatology Volume: 23 Pages: 254-259
  • DOI: 10.1007/s10165-012-0646-5
  • Peer Reviewed
• [Journal Article] Musculoskeletal ultrasonography assists the diagnostic performance of the 2010 classification criteria for rheumatoid arthritis (2013)
  • Author(s): Kawashiri S, Suzuki T, Okada A, Yamasaki S, Tamai M, Nakamura H, Origuchi T, Mizokami A, Uetani M, Aoyagi K, Eguchi K, Kawakami A
  • Journal Title: Modern rheumatology Volume: 23 Pages: 36-43
  • DOI: 10.1007/s10165-012-0628-7
  • Peer Reviewed
• [Journal Article] Confirmation of effectiveness of tocilizumab by ultrasonography and magnetic resonance imaging in biologic agent-naive early-stage rheumatoid arthritis patients (2013)
  • Author(s): Kawashiri S, Suzuki T, Nakashima Y, Horai Y, Okada A, Iwamoto N, Ichinose K, Arima K, Tamai M, Nakamura H, Origuchi T, Uetani M, Aoyagi K, Kawakami A
  • Journal Title: Modern Rheumatology Volume: (Equib Ahead of Print)
  • DOI: 10.3109/14397595.2013.844394
  • Peer Reviewed
• [Journal Article] Delayed treatment with tumor necrosis factor inhibitors in incomplete responders to synthetic disease-modifying anti-rheumatic drugs shows an excellent effect in patients with very early rheumatoid arthritis with poor prognosis factors (2012)
  • Author(s): Kita J, Tamai M, Arima K, Nakashima Y, Suzuki T, Kawashiri SY, Okada A, Koga T, Yamasaki S, Nakamura H, Origuchi T, Aramaki T, Nakashima M, Fujikawa K, Tsukada T, Ida H, Aoyagi K, Uetani M, Eguchi K, Kawakami A
  • Journal Title: Modern Rheumatology Volume: 25 Pages: 195-201
  • DOI: 10.1007/s10165-011-0511-y
  • Peer Reviewed
• [Journal Article] Treatment discontinuation in patients with very early rheumatoid arthritis in sustained simplified disease activity index remission after synthetic disease-modifying anti-rheumatic drug administration (2012)
  • Author(s): Kita J, Tamai M, Arima K, Nakashima Y, Suzuki T, Kawashiri SY, Iwamoto N, Okad63a A, Koga T, Yamasaki S, Nakamura H, Origuchi T, Ida H, Aoyagi K, Uetani M, Eguchi K, Kawakami A
  • Journal Title: Modern Rheumatology Volume: 22 Pages: 346-352
  • DOI: 10.1007/s10165-011-0522-8
  • Peer Reviewed
• [Journal Article] Magnetic resonance imaging (MRI) detection of synovitis and bone lesions of the wrists and finger joints in early-stage rheumatoid arthritis: comparison of the accuracy of plain MRI-based findings and gadolinium-diethylenetriamine pentaacetic acid-enhanced MRI-based findings (2012)
  • Author(s): Tamai M, Kawakami A, Uetani M,Fukushima A, Arima K, Fujikawa K, Iwamoto N, Aramaki T, Kamachi M, Nakamura H, Ida H, Origuchi T, Aoyagi K, Eguchi K
  • Journal Title: Modern Rheumatology Volume: 22 Pages: 654-658
  • DOI: 10.1007/s10165-011-0575-8
  • Peer Reviewed
• [Journal Article] Magnetic resonance imaging of wrist and finger joints distinguishes secondary Sjogren's syndrome with rheumatoid arthritis from primary Sjogren's syndrome with articular manifestations (2011)
  • Author(s): Iwamoto N, Kawakami A, Tamai M, Arima K, Nakamura H, Kawashiri SY, Kita J, Okada A, Koga T, Kamachi M, Yamasaki S, Ichise K, Inoda H, Origuchi T, Uetani M, Eguchi K
  • Journal Title: Clinical and Experimental Rheumatology Volume: 29 Pages: 1062-1063
  • DOI: 10.1007/s10165-010-0375-6
  • Peer Reviewed
• [Journal Article] Comparative study of the detection of joint injury in early-stage rheumatoid arthritis by magnetic resonance imaging of the wrist and finger joints and physical examination (2011)
  • Author(s): Tamai M, Kawakami A, Iwamoto N,Kawashiri SY, Fujikawa K, Aramaki T, Kita J, Okada A, Koga T, Arima K, Kamachi M,Yamasaki S, Nakamura H, Ida H, Origuchi T,Takao S, Aoyagi K, Uetani M, Eguchi K
  • Journal Title: Arthritis Care & Research Volume: 63 Pages: 436-439
  • DOI: 10.1007/s10165-010-0375-6
  • Peer Reviewed
• [Presentation] リウマチ性疾患のMRI (2014)
  • Author(s): 上谷雅孝,玉井慎美,川上純
  • Organizer: 第58回日本リウマチ学会
  • Place of Presentation: 東京 (教育研修講演)
  • Year and Date: 2014-04-25
• [Presentation] 画像診断の進歩 MRI を用いた関節リウマチの画像評価 (2014)
  • Author(s): 上谷雅孝,玉井慎美,川上純
  • Organizer: 第58回日本リウマチ学会
  • Place of Presentation: 東京 (シンポジウム)
  • Year and Date: 2014-04-25
• [Presentation] Combination of magneticimaging (MRI)- proven osteitis with 2010 RA classification criteria improves the diagnostic probability of rheumatoid arthritis (RA) (2013)
  • Author(s): Tamai M, Kita K, Nakashima Y, Nishino A, Suzuki T, Horai Y, Okada A, Koga T,Kawashiri S, Iwamoto N, Ichinose K, Arima K, Yamasaki S, Nakamura H, Origuchi T, Uetani M, Fukushima A, Aoyagi K, Eguchi K, Kawakami A
  • Organizer: ACR/AHRP meeting 2012
  • Place of Presentation: San Diego, USA
  • Year and Date: 20131025-30
• [Presentation] Stringent therapies improve both radiographic and clinical outcome in early-stage RA patients from Japanese population: longitudinal study from Nagasaki early arthritis cohort (2013)
  • Author(s): Tamai M, Nakashima Y, Suzuki T, Kita J, Okada A, Kawashiri S, Iwamoto N,Ichinose K, Arima K, Nakamura H, Origuchi T, Uetani M, Aoyagi K, Eguchi K, Kawakami A
  • Organizer: ACR/AHRP meeting 2013
  • Place of Presentation: San Diego, USA
  • Year and Date: 20131025-30
• [Presentation] The severity of synovial inflammation assessed by musculoskeletal ultrasonography correlates with that of osteitis assessed by magnetic resonance imaging in patients with rheumatoid arthritis (2013)
  • Author(s): Kawashiri S, Suzuki T, Nakashima Y,Horai Y, Okada A, Iwamoto N, Ichinose K,Arima K, Tamai M, Nakamura H, Origuchi T,Uetani M, Aoyagi K, Eguchi K, Kawakami A
  • Organizer: EULAR 2013
  • Place of Presentation: Madrid, Spain
  • Year and Date: 20130712-15
• [Presentation] Combination of magnetic imaging (MRI)-proven osteitis with 2010 RAclassification criteria improves the diagnostic probability of rheumatoid arthritis (RA) (2013)
  • Author(s): Tamai M, Nakashima Y, Suzuki T, Kita J, Okada A, Kawashiri S, Iwamoto N,Ichinose K, Arima K, Nakamura H, Origuchi T, Uetani M, Aoyagi K, Eguchi K, Kawakami A
  • Organizer: EULAR 2013
  • Place of Presentation: Madrid, Spain
  • Year and Date: 20130712-15
• [Presentation] Combination of magnetic imaging (MRI)- proven osteitis with 2010 RA classification criteria improves the diagnostic probability of rheumatoid arthritis (RA) (2012)
  • Author(s): Tamai M, Nakashima Y, Suzuki T,Horai Y, Okada K, Kita J, Kawashiri S, Iwamoto N, Ichinose K, Arima K, Nakamura H,Origuchi T, Uetani M, Aoyagi K, Eguchi K,Kawakami A
  • Organizer: ACR/AHRP meeting 2012
  • Place of Presentation: Washington, USA
  • Year and Date: 20121110-14
• [Presentation] The presence of magnetic resonancc imaging-proven osteitis at entry predicts the development of rapid radiographic progression in patients with early rhewmtoid arthritis (2012)
  • Author(s): Tamai M, Nakashima Y, Suzuki T, Okada K, Kita J, Horai Y, Iwamoto N, Ichinose K,Arima K, Yamasaki S, Nakamura H, Origuchi T, Uetani M, Aoyagi K, Eguchi K, Kawakami A
  • Organizer: EULAR2012
  • Place of Presentation: Berlin, Germany
  • Year and Date: 20120606-09
• [Presentation] 初期関節リウマチの診断と治療 放射線科から:MRIによる早期関節リウマチの診断と病態把握 (2012)
  • Author(s): 上谷雅孝
  • Organizer: 第31回日本画像医学会
  • Place of Presentation: 東京 (シンポジウム)
  • Year and Date: 2012-02-17
• [Presentation] Evaluation of the patients with early arthritis by 2010 RA criteria in conjunction with MRI of wrists and finger joints (2011)
  • Author(s): Tamai M, Arima K, Uetani M, Iwamoto N,Kita J, Okada A, Koga T, Kawashiri SY,Ichinose K, Yamasaki S, Nakamura H, Ida H,Origuchi T, Aoyagi K, Eguchi K, Kawakami A
  • Organizer: ACR/ARHP Meeting 2011
  • Place of Presentation: Chicago, USA
  • Year and Date: 20111105-09
• [Presentation] Evaluation of the patients with early arthritis by 2010 ACR/EULAR criteria in conjunction with MRI of wrists and finger joints (2011)
  • Author(s): Tamai M, Arima K, Iwamoto N, Okada A,Kita J, Koga T, Kawashiri SY, Yamasaki S,Nakamura H, Origuchi T, Uetani M, Aoyagi K, Eguchi K, Kawakami A
  • Organizer: EULAR 2011
  • Place of Presentation: London, UK
  • Year and Date: 20110526-29
• [Presentation] 放射線科医からみたリウマチ疾患の画像診断・若手医師への提言 炎症性滑膜炎 関節リウマチとその類縁疾患 (2011)
  • Author(s): 上谷雅孝,城戸康男
  • Organizer: 第55回日本リウマチ学会総会・学術集会
  • Place of Presentation: 神戸
  • Year and Date: 2011-07-19
• [Book] 関節のMRI(第2 版) (2013)
  • Author(s): 福田国彦,杉本英治,上谷雅孝 (江原茂 編集)
  • Publisher: メディカル・サイエンス・インターナショナル