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2013 Fiscal Year Final Research Report

Development of the techniques to use the 3T high-resolution MR images for radiation therapy planning in patients with glioma

Research Project

  • PDF
Project/Area Number 23591780
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeMulti-year Fund
Section一般
Research Field Radiation science
Research InstitutionKumamoto University

Principal Investigator

KITAJIMA Mika  熊本大学, 医学部附属病院, 准教授 (60305018)

Co-Investigator(Kenkyū-buntansha) HIRAI Toshinori  熊本大学, 生命科学研究部, 准教授 (40274724)
SHIGEMATSU Yoshinori  熊本大学, 医学部附属病院, 助手 (00555766)
MAKINO Keishi  熊本大学, 医学部附属病院, 講師 (90381011)
NAKAMURA Hideo  熊本大学, 医学部附属病院, 講師 (30359963)
SHIRAISHI Shinya  熊本大学, 生命科学研究部, 助教 (50433008)
OYA Natsuo  熊本大学, 生命科学研究部, 教授 (70281095)
Project Period (FY) 2011 – 2013
Keywords核磁気共鳴画像(MRI) / 脳腫瘍
Research Abstract

First, we optimized the sequence parameters of three dimensional (3D) high-resolution images to obtain the high contrast between the cortex and white matter. We validated that 3D FLAIR could delineate the white matter tracts and nuclei with high contrast in normal volunteers. In patients with glioma, we compared between 3D MR imaging findings (MPARGE, FLAIR, T2-weighted images) and histopathologic findings. The signal-to-noise ratio and the cellular proliferation index were correlated. In addition, we evaluated the effect of contrast agent to 3D phase difference enhanced image (PADRE). Contrast enhanced PADRE delineated the relationship between enhanced glioblastomas and adjacent structures better than non-contrast enhanced PADRE. In the technical study, we developed the software for automatic quantification of MR image distortion. Our results indicated that the 3D high-resolution MR images could be used as images for radiation therapy planning.

  • Research Products

    (4 results)

All 2013 2012

All Journal Article (2 results) (of which Peer Reviewed: 2 results) Presentation (2 results)

  • [Journal Article] Can MRI-derived factors predict the survival in glioblastoma patients treated with postoperative chemoradiation therapy?2013

    • Author(s)
      Nakamura H, Murakami R, Hirai T, Kitajima M, Yamashita Y
    • Journal Title

      Acta Radiol

      Volume: 54(2) Pages: 214-220

    • DOI

      10.1258/ar.2012.120525

    • Peer Reviewed
  • [Journal Article] Comparison of 3D FLAIR, 2D FLAIR, and 2D T2-Weighted MR Imaging of Brain Stem Anatomy2012

    • Author(s)
      Kitajima M, Hirai T, Shigematsu Y, Uetani H, Iwashita K, Morita K, Komi M, Yamashita Y
    • Journal Title

      AJNR Am J Neuroradiol

      Volume: 33(5) Pages: 922-927

    • DOI

      10.3174/ajnr.A2874

    • Peer Reviewed
  • [Presentation] 位相差強調画像におけるガドリニウム造影剤の影響2013

    • Author(s)
      北島美香
    • Organizer
      第41回日本磁気共鳴学会大会
    • Place of Presentation
      アスティとくしま(徳島県徳島市)
    • Year and Date
      20130919-21
  • [Presentation] 3次元的な歪み計測のための3Dファントムを用いた歪みの自動計測法の開発2013

    • Author(s)
      氏原晋太郎
    • Organizer
      第41回日本磁気共鳴学会大会
    • Place of Presentation
      アスティとくしま(徳島県徳島市)
    • Year and Date
      20130919-21

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Published: 2015-07-16  

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