2013 Fiscal Year Final Research Report
Development of molecular Imaging for a new amyloidosis (AD,FAP)
| Project/Area Number |
23591781
|
|---|
| Research Category |
Grant-in-Aid for Scientific Research (C)
|
| Allocation Type | Multi-year Fund |
|---|
| Section | 一般 |
|---|
| Research Field |
Radiation science
|
|---|
| Research Institution | Kumamoto University |
|---|
Principal Investigator |
|
|---|
| Co-Investigator(Renkei-kenkyūsha) |
ANDO Yukio 熊本大学, 大学院生命科学研究部, 教授 (20253742)
IKEDA Manabu 熊本大学, 大学院生命科学研究部, 教授 (60284395)
TOMIGUCHI Seiji 熊本大学, 大学院生命科学研究部, 教授 (20172182)
|
|---|
| Project Period (FY) |
2011 – 2013
|
| Keywords | PET / アルツハイマー病 / SPECT / 標識合成 |
|---|
| Research Abstract |
[11C]PIB was synthesized and evaluated Quality control for Clinical use. By applying purification system,Radiochemical yield was 62.7% and radiochemical purity was 95% and more. On the other hand, EMSB (1-(2-mestyl-ethoxy)-2,5bis (phenylstyryl)benzene) is newly synthesized and (1-(125I-ethoxy)-2,5-bis (phenylstyryl) benzene) [125I]-EISB was obtained. The radiochemical yield and the radiochemical purity were 80-90% and 98.4% respectively. We injected [125I]-EISB to Alzheimer model mouse and analyzed its bio-distribution (%dose/g) of [125I]-EISB in the amyloid tissues. In the animal experiments showed that the bio-distribution (%dose/g) of [125I]-EISB gave a similar to the uptake as well as fluorescent agents MSB and PIB which have done in our institute. [125I]-EISB was a promising new radio-compound for the detection of the amyloid protein and make it possible to apply it to clinical use.
|
