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2013 Fiscal Year Final Research Report

Development of molecular Imaging for a new amyloidosis (AD,FAP)

Research Project

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Project/Area Number 23591781
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeMulti-year Fund
Section一般
Research Field Radiation science
Research InstitutionKumamoto University

Principal Investigator

TOMIYOSHI Katsumi  熊本大学, 生命科学研究部, 教授 (60188802)

Co-Investigator(Renkei-kenkyūsha) ANDO Yukio  熊本大学, 大学院生命科学研究部, 教授 (20253742)
IKEDA Manabu  熊本大学, 大学院生命科学研究部, 教授 (60284395)
TOMIGUCHI Seiji  熊本大学, 大学院生命科学研究部, 教授 (20172182)
Project Period (FY) 2011 – 2013
KeywordsPET / アルツハイマー病 / SPECT / 標識合成
Research Abstract

[11C]PIB was synthesized and evaluated Quality control for Clinical use. By applying purification system,Radiochemical yield was 62.7% and radiochemical purity was 95% and more. On the other hand, EMSB (1-(2-mestyl-ethoxy)-2,5bis (phenylstyryl)benzene) is newly synthesized and (1-(125I-ethoxy)-2,5-bis (phenylstyryl) benzene) [125I]-EISB was obtained. The radiochemical yield and the radiochemical purity were 80-90% and 98.4% respectively. We injected [125I]-EISB to Alzheimer model mouse and analyzed its bio-distribution (%dose/g) of [125I]-EISB in the amyloid tissues. In the animal experiments showed that the bio-distribution (%dose/g) of [125I]-EISB gave a similar to the uptake as well as fluorescent agents MSB and PIB which have done in our institute. [125I]-EISB was a promising new radio-compound for the detection of the amyloid protein and make it possible to apply it to clinical use.

  • Research Products

    (6 results)

All 2014 2013 2012 Other

All Journal Article (1 results) (of which Peer Reviewed: 1 results) Presentation (4 results) Remarks (1 results)

  • [Journal Article] Novel styrylbenzene derivatives for detecting amyloid deposits2014

    • Author(s)
      Nakazono M.,Obayashi,K., Sasamoto K.,Tomiyoshi,K.,Suenaga, G., Ando,Y.
    • Journal Title

      Clinica Chimica Acta

      Volume: (In Press) (Ref. No.: CCA-D-14-00296R1)

    • Peer Reviewed
  • [Presentation] Bio-Distribution experiments of mice using a New Amyloido Imaging Probe ^<125>I-EISB for Clinical Use2013

    • Author(s)
      Sho Tsukimoto, Konen Obyashi, Katsumi Tomiyoshi
    • Organizer
      International SYnposium on Familial Amyloidotic Polynneuropathy
    • Place of Presentation
      Auditorio do Centro de Convencoes Antonio Seabra Moggi, Riode Janeiro Brazil
    • Year and Date
      20131010-13
  • [Presentation] アルツハイマー病の放射性薬剤につい^<11>C-PIBの標識合成と品質管理2013

    • Author(s)
      冨吉勝美
    • Organizer
      第50回放射線影響懇話会
    • Place of Presentation
      佐賀大学
    • Year and Date
      2013-07-27
  • [Presentation] 新たに開発した試薬EFSBを用いた各種アミロイドーシスの組織学的診断2012

    • Author(s)
      小田孝太郎、大林光念、安東由喜雄、冨吉勝美
    • Organizer
      九州放射線技術学会
    • Place of Presentation
      長崎大学
    • Year and Date
      20121124-25
  • [Presentation] ^<11>C-PIBの標識合成と分取精製2012

    • Author(s)
      高橋俊輔、盛島由貴、冨吉勝美
    • Organizer
      九州放射線技術学会
    • Place of Presentation
      長崎大学
    • Year and Date
      20121124-25
  • [Remarks] 「アミロイド変性症(AD,FAP)の分子イメージング診断法の開発」

    • URL

      http://www.molimaging.hs.kumamoto-u.ac.jp/

URL: 

Published: 2015-07-16  

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