Development of a high-speed energy-dispersive X-ray computed tomography system and its application to molecular-level imaging

2013 Fiscal Year Final Research Report

• Project/Area Number: 23591791
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Multi-year Fund
• Section: 一般
• Research Field: Radiation science
• Research Institution: Iwate Medical University
• Principal Investigator: SATO Eiichi 岩手医科大学, 公私立大学の部局等, 教授 (90154038)
• Co-Investigator(Renkei-kenkyūsha): ODA Yasuyuki 岩手医科大学, 教養教育センター, 助教 (50583671) ; SAGAE Michiaki 岩手医科大学, 教養教育センター, 助教 (30235197)
• Project Period (FY): 2011 – 2013
• Keywords: Ｘ線CT / エネルギー弁別CT / 高速CdTe検出器 / LSO-MPPC検出器 / YAP(Ce)-MPPC検出器 / ヨウ素KエッジCT / ガドリニウムKエッジCT / エネルギーサブトラクション

Research Abstract

In the present research, we developed an energy-dispersive X-ray computed tomography (ED-CT) system using a 25 mm/s linear CdTe scanner, a turntable, and an X-ray generator. Using this ED-CT with a maximum count rate of sub-Mcps, we performed enhanced K-edge imaging using iodine and gadolinium contrast media, and blood vessels and cancerous regions were observed at high contrast. Using the CdTe detector in conjunction with an x-y stage, we also developed a transmission-type camera, a reflection-type fluorescence camera, and a back-scattering X-ray camera. To carry out Mcps-range imaging, we developed LSO-MPPC and YAP(Ce)-MPPC detectors. Using these two detectors, we constructed the ED-CT system and performed high-speed K-edge imaging. Lately, a dual-energy comparator device was developed, and dual-energy subtraction was performed using two different energy images which were obtained simultaneously.

Research Products

• [Journal Article] Zero-dark-counting high-speed X-ray photon detection using a cerium-doped yttrium aluminum perovskite crystal and a small photomultiplier tube and its application to gadolinium imaging (2014)
  • Author(s): S. Yamaguchi, E. Sato, Y. Oda, R. Nakamura, H. Oikawa, T. Yabuushi, H. Ariga, S. Ehara
  • Journal Title: Jpn. J. Appl. Phys Volume: 53 Pages: 040304-1-4
  • Peer Reviewed
• [Journal Article] Zero-dark-counting X-ray photon detection using a YAP(Ce)-MPPC detector and its application to computed tomography using gadolinium contrast media (2014)
  • Author(s): S. Kami, E. Sato, H. Kogita, W. Numahata, T. Hamaya, S. Nihei, Y. Arakawa, Y. Oda, H. Kodama, O. Hagiwara, H. Matsukiyo, A. Osawa, T. Enomoto, M. Watanabe, S. Kusachi, S. Sato, A. Ogawa
  • Journal Title: Rad. Phys. Chem Volume: 100 Pages: 1-7
  • Peer Reviewed
• [Journal Article] Investigation of X-ray photon-counting using ceramic-substrate silicon diode and its application to gadolinium imaging (2014)
  • Author(s): Y. Arakawa, E. Sato, H. Kogita, T. Hamaya, S. Nihei, W. Numahata, S. Kami, Y. Oda, O. Hagiwara, H. Matsukiyo, A. Osawa, T. Enomoto, M. Watanabe, S. Kusachi, S. Sato, A. Ogawa
  • Journal Title: Jpn. J. Appl. Phys Volume: 53 Pages: 072201-1-5
  • Peer Reviewed
• [Journal Article] Image-quality improvement in pileup-less cadmium-telluride X-ray computed tomography using a frequency-voltage converter and its application to iodine imaging (2014)
  • Author(s): A. Shimamura, E. Sato, S. Shikanai, K. Kitakami, I. Nakaya, W. Nishikawa, Y. Sato, S. Yamaguchi, Y. Oda, O. Hagiwara, H. Matsukiyo, T. Enomoto, M. Watanabe, S. Kusachi, S. Ehara
  • Journal Title: Med. Imag. Inform. Sci Volume: 31(in press)
  • Peer Reviewed
• [Journal Article] Low-dose-rate computed tomography system utilizing 25 mm/s-scan silicon X-ray diode and its application to iodine K-edge imaging using filtered bremsstrahlung photons (2013)
  • Author(s): R. Matsushita, E. Sato, Y. Yanbe, H. Chiba, T. Maeda, O. Hagiwara, H. Matsukiyo, A. Osawa, T. Enomoto, M. Watanabe, S. Kusachi, S. Sato, A. Ogawa, J. Onagawa
  • Journal Title: Jpn. J. Appl. Phys Volume: 52 Pages: 032202-1-5
  • Peer Reviewed
• [Journal Article] X-ray photon counting using 100 MHz ready-made silicon P-intrinsic-N X-ray diode and its application to energy-dispersive computed tomography (2013)
  • Author(s): H. Kodama, M. Watanabe, E. Sato, Y. Oda, O. Hagiwara, H. Matsukiyo, A. Osawa, T. Enomoto, S. Kusachi, S. Sato, A. Ogawa
  • Journal Title: Jpn. J. Appl. Phys Volume: 52 Pages: 072202-1-6
  • Peer Reviewed
• [Journal Article] High-sensitivity high-speed X-ray fluorescence scanning cadmium telluride detector for deep-portion cancer diagnosis utilizing tungsten-Kα-excited gadolinium mapping (2013)
  • Author(s): Y. Yanbe, E. Sato, H. Chiba, T. Maeda, R. Matsushita, Y. Oda, O. Hagiwara, H. Matsukiyo, A. Osawa, T. Enomoto, M. Watanabe, S. Kusachi, S. Sato, A. Ogawa
  • Journal Title: Jpn. J. Appl. Phys Volume: 52 Pages: 092201-1-4
  • Peer Reviewed
• [Journal Article] Investigation of dark-count-less Lu_2(SiO_4)O-multipixel-photon detector and its application to photon counting X-ray computed tomography using iodine media (2013)
  • Author(s): E. Sato, Y. Oda, H. Kodama, O. Hagiwara, H. Matsukiyo, A. Osawa, T. Enomoto, M. Watanabe, S. Kusachi, S. Sato, A. Ogawa
  • Journal Title: Jpn. J. Appl. Phys Volume: 52 Pages: 092401-1-6
  • Peer Reviewed
• [Journal Article] X-ray detection using a ceramic-substrate silicon X-ray diode and its application to computed tomography using gadolinium media (2013)
  • Author(s): Y. Oda, E. Sato, M. Sagae, O. Hagiwara, H. Matsukiyo, A. Osawa, T. Enomoto, M.Watanabe, S. Kusachi, S. Sato, A. Ogawa
  • Journal Title: Med. Imag. Inform. Sci Volume: 29 Pages: 70-75
  • Peer Reviewed
• [Journal Article] 15 Mcps photon-counting X-ray computed tomography system using a ZnO-MPPC detector and its application to gadolinium imaging (2012)
  • Author(s): E. Sato, S. Sugimura, H. Endo, Y. Oda, A. Abudurexiti, O. Hagiwara, A. Osawa, H. Matsukiyo, T. Enomoto, M. Watanabe, S. Kusachi, S. Sato, A. Ogawa, J. Onagawa
  • Journal Title: Appl. Rad. Isot Volume: 70 Pages: 336–340
  • Peer Reviewed
• [Journal Article] Demonstration of enhanced iodine K-edge imaging using an energy-dispersive X-ray computed tomography system with a 25 mm/s-scan linear cadmium telluride detector and a single comparator (2012)
  • Author(s): E. Sato, Y. Oda, A. Abudurexiti, O. Hagiwara, H. Matsukiyo, A. Osawa, T. Enomoto, M. Watanabe, S. Kusachi, S. Sato, A. Ogawa, J. Onagawa
  • Journal Title: Appl. Rad. Isot Volume: 70 Pages: 831–836
  • Peer Reviewed
• [Journal Article] Investigation of energy-dispersive X-ray computed tomography system with CdTe scan detector and comparing-differentiator and its application to gadolinium K-edge imaging (2012)
  • Author(s): H. Chiba, Y. Sato, E. Sato, T. Maeda, R. Matsushita, Y. Yanbe, O. Hagiwara, H. Matsukiyo, A. Osawa, T. Enomoto, M. Watanabe, S. Kusachi, S. Sato, A. Ogawa, J. Onagawa
  • Journal Title: Jpn. J. Appl. Phys Volume: 51 Pages: 102402-1-5
  • Peer Reviewed
• [Journal Article] Investigation of a high-count-rate energy-disiersive X-ray CT system using a CdTe detector and a high-speed comparator and its application to iodine K-edge imaging (2012)
  • Author(s): Y. Sato, E. Sato, S. Ehara, Y. Oda, O. Hagiwara, H. Matsukiyo, A. Osawa, T. Enomoto, M. Watanabe, S. Kusachi, S. Sato, A. Ogawa, J. Onagawa
  • Journal Title: Med. Imag. Inform. Sci Volume: 29 Pages: 56-61
  • Peer Reviewed
• [Journal Article] 100μA-100 kV photon-counting X-ray computed tomography system using an LSO-MPPC detector and a high-speed comparator and its application to gadolinium imaging (2012)
  • Author(s): T. Maeda, E. Sato, R. Matsushita, Y. Yanbe, H. Chiba, Y. Oda, O. Hagiwara, H. Matsukiyo, A. Osawa, T. Enomoto, M. Watanabe, S. Kusachi, S. Sato, A. Ogawa, J. Onagawa
  • Journal Title: J. Med. Imag. Radiat. Sci Volume: 43 Pages: 149-154
  • Peer Reviewed
• [Journal Article] 250 kcps photon-counting X-ray CT system using a YAP(Ce) detector and a high-speed inverse comparator and its application to iodine imaging (2012)
  • Author(s): Y. Sato, E. Sato, S. Ehara, Y. Oda, O. Hagiwara, H. Matsukiyo, A. Osawa, T. Enomoto, M. Watanabe, S. Kusachi, S. Sato, A. Ogawa, J. Onagawa
  • Journal Title: Med. Imag. Inform. Sci Volume: 29 Pages: 51-55
  • Peer Reviewed
• [Journal Article] Demonstration of 10 keV-width K-edge Imaging Using an Energy-Discrimination X-ray Computed Tomography System Utilizing a Silicon-PIN Detector (2011)
  • Author(s): O. Hagiwara, M. Watanabe, E. Sato, H. Matsukiyo, A. Osawa, J. Nagao
  • Journal Title: Med. Imag. Inform. Sci Volume: 28 Pages: 24-29
  • Peer Reviewed
• [Journal Article] Conventional X-ray fluorescence camera with a cadmium-telluride detector and its application to cancer diagnosis (2011)
  • Author(s): T. Enomoto, E. Sato, P. Abderyim, A. Abudurexiti, O. Hagiwara, H. Matsukiyo, A. Osawa, M. Watanabe, J. Nagao, S. Sato, A. Ogawa, J. Onagawa
  • Journal Title: Nucl. Instr. Meth. A Volume: 635 Pages: 108–115
  • Peer Reviewed
• [Journal Article] First demonstration of 10 keV-width energy-discrimination K-edge radiography using a cadmium-telluride X-ray camera with a tungsten-target tube (2011)
  • Author(s): M. Watanabe, E. Sato, P. Abderyim, A. Abudurexiti, O. Hagiwara, H. Matsukiyo, A. Osawa, T. Enomoto, J. Nagao, S. Sato, A. Ogawa, J. Onagawa
  • Journal Title: Nucl. Instr. Meth. A Volume: 637 Pages: 171–177
  • Peer Reviewed
• [Journal Article] Monochromatic flash embossed radiography using clean K photons from a spherical-plasma target (2011)
  • Author(s): A. Osawa, E. Sato, Y. Oda, A. Abudurexiti, P. Abderyim, O. Hagiwara, H. Matsukiyo, T. Enomoto, M. Watanabe, J. Nagao, S. Sato, A. Ogawa, J. Onagawa
  • Journal Title: Nucl. Instr. Meth. A Volume: 635 Pages: 131–136
  • Peer Reviewed
• [Journal Article] Application of an oscillation-type linear cadmium telluride detector to enhanced gadolinium K-edge computed tomography (2011)
  • Author(s): H. Matsukiyo, E. Sato, O. Hagiwara, A. Abudurexiti, A. Osawa, T. Enomoto, M. Watanabe, J. Nagao, S. Sato, A. Ogawa, J. Onagawa
  • Journal Title: Nucl. Instr. Meth. A Volume: 632 Pages: 142–146
  • Peer Reviewed
• [Journal Article] First demonstration of iodine mapping in nonliving phantoms using an X-ray fluorescence computed tomography system with a cadmium telluride detector and a tungsten-target tube (2011)
  • Author(s): E. Sato, Y. Sato, S. Ehara, A. Abudurexiti, O. Hagiwara, H. Matsukiyo, A. Osawa, T. Enomoto, M. Watanabe, J. Nagao, S. Sato, A. Ogawa, J. Onagawa
  • Journal Title: Nucl. Instr. Meth. A Volume: 638 Pages: 187-191
  • Peer Reviewed
• [Journal Article] Iodine X-ray fluorescence computed tomography system utilizing a cadmium telluride detector in conjunction with a cerium-target tube (2011)
  • Author(s): O. Hagiwara, M. Watanabe, E. Sato, H. Matsukiyo, A. Osawa, T. Enomoto, J. Nagao, S. Sato, A. Ogawa, J. Onagawa
  • Journal Title: Nucl. Instr. Meth. A Volume: 640 Pages: 170-175
  • Peer Reviewed
• [Journal Article] Energy-discrimination X-ray computed tomography system utilizing a silicon-PIN detector and its application to 2.0-keV-width K-edge imaging (2011)
  • Author(s): O. Hagiwara, M. Watanabe, E. Sato, H. Matsukiyo, A. Osawa, T. Enomoto, J. Nagao, S. Sato, A. Ogawa, J. Onagawa
  • Journal Title: Nucl. Instr. Meth. A Volume: 638 Pages: 165-170
  • Peer Reviewed
• [Journal Article] Mcps-range photon-counting X-ray computed tomography system utilizing an oscillating linear-YAP(Ce) photon detector (2011)
  • Author(s): Y. Oda, E. Sato, A. Abudurexiti, O. Hagiwara, A. Osawa, H. Matsukiyo, T. Enomoto, M. Watanabe, S. Kusachi, S. Sugimura, H. Endo, S. Sato, A. Ogawa, J. Onagawa
  • Journal Title: Nucl. Instr. Meth. A Volume: 643 Pages: 69-74
  • Peer Reviewed
• [Journal Article] 6 Mcps-range photon-counting X-ray computed tomography system using a 25 mm/s-scan linear LSO-MPPC detector and its application to gadolinium imaging (2011)
  • Author(s): E. Sato, Y. Oda, A. Abudurexiti, O. Hagiwara, H. Matsukiyo, A. Osawa,T. Enomoto, M. Watanabe, S. Kusachi, S. Sugimura, H. Endo, S. Sato, A. Ogawa, J. Onagawa
  • Journal Title: Rad. Phys. Chem Volume: 80 Pages: 1327-1332
  • Peer Reviewed
• [Patent(Industrial Property Rights)] ダークカウントレス放射線検出エネル ギー弁別イメージングシステム (2014)
  • Inventor(s): 佐藤英一
  • Industrial Property Rights Holder: 岩手医科大学
  • Industrial Property Rights Type: 特許
  • Industrial Property Number: 2014-024663
  • Filing Date: 2014-02-12
  • Overseas
• [Patent(Industrial Property Rights)] X線直接変換イメージングシステム (2013)
  • Inventor(s): 佐藤英一
  • Industrial Property Rights Holder: 岩手医科大学
  • Industrial Property Rights Type: 特許
  • Industrial Property Number: 2013-170500
  • Filing Date: 2013-08-20
  • Overseas