2013 Fiscal Year Final Research Report
Regional glucose metabolic reduction in dementia with Lewy bodies is independent of amyloid deposition
| Project/Area Number |
23591804
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Radiation science
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| Research Institution | Kinki University |
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Principal Investigator |
ISHII Kazunari 近畿大学, 医学部附属病院, 教授 (50534103)
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| Co-Investigator(Kenkyū-buntansha) |
MURAKAMI Takamichi 近畿大学, 医学部, 教授 (20252653)
OKADA Masahiro 近畿大学, 医学部, 講師 (20296700)
KUMANO Seishi 近畿大学, 医学部, 講師 (70335339)
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| Project Period (FY) |
2011 – 2013
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| Keywords | 認知症 / レビー小体型認知症 / PET / アミロイド / 糖代謝 / 脳 / アルツハイマー病 / パーキンソン病 |
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| Research Abstract |
The purpose of this study was to clarify whether regional hypometabolism is related to amyloid deposits in the dementia with Lewy bodies (DLB) brain. Methods: Ten consecutive subjects with DLB and 10 Alzheimer disease (AD) patients who underwent both PiB-PET and FDG-PET were included in this study. Regional standardized uptake value ratio (SUVR)s normalised to cerebellar cortices were calculated in the FDG and PiB PET images.Results: All AD patients and five DLB patients showed amyloid deposits (PiB positive). The parietotemporal and occipital metabolism in the DLB group were significantly lower than those in the AD group. In DLB patients, there were no differences in regional glucose metabolism between PiB positive and negative patients. Conclusions: In the DLB brain, decreased regional glucose metabolism is unrelated to amyloid deposits, although the hypometabolic area overlaps with the AD hypometabolic area.
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[Journal Article] the J-ADNI Study Group. Visual-Statistical Interpretation of 18F-FDG-PET Images for Characteristic Alzheimer Patterns in a Multicenter Study : Inter-Rater Concordance and Relationship to Automated Quantitative Evaluation2014
Author(s)
Yamane T, Ikari Y, Nishio T, Ishii K, Ishii K, Kato T, Ito K, Silverman DH, Senda M, Asada T, Arai H, Sugishita M, Iwatsubo T
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Journal Title
AJNR Am J Neuroradiol
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Pages: 244-249
Peer Reviewed
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Ito K, Mori E, Fukuyama H, Ishii K, Washimi Y, Asada T, Mori S, Meguro K, Kitamura S, Hanyu H, Nakano S, Matsuda H, Kuwabara Y, Hashikawa K, Momose T, Uchida Y, Hatazawa J, Minoshima S, Kosaka K, Yamada T, Yonekura Y; J-COSMIC Study Group
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Mori E, Ishikawa M, Kato T, Kazui H, Miyake H, Miyajima M, Nakajima M, Hashimoto M, Kuriyama N, Tokuda T, Ishii K, Kaijima M, Hirata Y, Saito M, Arai H
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Sakakibara R, Uchida Y, Ishii K, Kazui H, Hashimoto M, Ishikawa M, Yuasa T, Kishi M, Ogawa E, Tateno F, Uchiyama T, Yamamoto T, Yamanishi T, Terada H
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Journal Title
Neurourol Urodyn
Volume: 31
Pages: 50-55
Peer Reviewed
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[Presentation] Japanese Alzheimer's Disease Neuroimaging Initiative (J-ADNI). Effects of APOE epsilon 4 on regional cerebral amyloid deposition and gray matter atrophy in mild cognitive impairment with PiB-PET-confirmed amyloid pathology : Results from J-ADNI2013
Author(s)
Ishii K, Takahashi R, Matsuda H, Senda M, Ito K, Ishii K, Kato T, Kuwano R, Sugishita M, Asada T, Iwatsubo T
Organizer
Alzheimer's Association International Conference 2013
Place of Presentation
Boston
Year and Date
2013-07-15
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[Presentation] Distinguishing Neurodegenerative Dementia with MRI, FDG-PET, and PiB-PET2012
Author(s)
Ishii K, Hyodo T, Yamda Y, Takahashi H, Okada M, Murakami T, Hosono M, Kashiwagi N, Ashikaga R
Organizer
2012 RSNA
Place of Presentation
Chicago
Year and Date
20121125-30
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[Presentation] FDG-PET and automatic diagnosis systems for prediction of conversion to Alzheimer disease in subjects with mild cognitive impairments : Study on diagnosis of early Alzheimer disease-Japan (SEAD-J)2011
Author(s)
K. Ishii, K. Ito, M. Senda, K. Ishii, T. Kato, H. Fukuyama, Y. Ouchi, K. Meguro, A. Okumura, Y. Mitsuyama, SEAD-J Group
Organizer
Annual Congress of the European Association of Nuclear Medicine'11
Place of Presentation
Birmingham
Year and Date
2011-10-16
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