2013 Fiscal Year Final Research Report
PD-ECGF-targeted tumor imaging with new F-18 radiolabeled uracil derivatives
| Project/Area Number |
23591811
|
|---|
| Research Category |
Grant-in-Aid for Scientific Research (C)
|
| Allocation Type | Multi-year Fund |
|---|
| Section | 一般 |
|---|
| Research Field |
Radiation science
|
|---|
| Research Institution | Hokkaido University |
|---|
Principal Investigator |
Nishijima Ken-ichi 北海道大学, 医学(系)研究科(研究院), 特任講師 (60364254)
|
|---|
| Co-Investigator(Kenkyū-buntansha) |
大倉 一枝 北海道医療大学, 薬学部, 教授 (60094827)
|
|---|
| Project Period (FY) |
2011 – 2013
|
| Keywords | 放射性薬剤 / 癌 / チミジンホスホリラーゼ |
|---|
| Outline of Final Research Achievements |
The angiogenic factor PD-ECGF/ thymidine phosphorylase (TP) is expressed at high levels in a variety of solid tumors compared with normal tissue. In this study, we aimed at the development of F-18 radiopharmaceuticals for imaging of angiogenesis.
5-fluoro analog of IIMU and BOMU, a potent inhibitor of TP studied the synthesis was performed. We have succeeded in creating new compounds for TP. However F-labeled TP inhibitor was not given. The results of this study gave an important knowledge on to creating the F-18 labeled compounds.
|
| Free Research Field |
医歯薬学
|
