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2013 Fiscal Year Final Research Report

The development of a novel transcatheter arterial infusion chemotherapy and significance of combination with molecular targeted agents

Research Project

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Project/Area Number 23591821
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeMulti-year Fund
Section一般
Research Field Radiation science
Research InstitutionYamaguchi University

Principal Investigator

HIDAKA Isao  山口大学, 医学部附属病院, 助教 (70593440)

Co-Investigator(Kenkyū-buntansha) YAMASAKI Takahiro  山口大学, 大学院医学系研究科, 教授 (00304478)
UCHIDA Koichi  山口大学, 医学部附属病院, 講師 (80397992)
Project Period (FY) 2011 – 2013
Keywords肝動注化学療法 / 肝細胞癌 / 微小デンプン球 / ミリプラチン
Research Abstract

We designed a novel transcatheter arterial infusion chemotherapy as transvascular treatment for hepatocellular carcinoma, without the use of a solid embolic material, and the use of lipiodol and degradable starch microspheres (DSM). We investigated the efficancy of this therapy using cisplatin in clinical trial. In this study, we examined the usefulness of this new hepatic arterial infusion chemotherapy using miriplatin affinity with lipiodol better than cisplatin. In 2011, we start a prospective randomized study by two groups (DSM non-combination group, DSM combination group). So far, we treated in 30 cases. At the moment, progression-free survival tend to extended in DSM combination group, andresponse rate to be high in DSM combination group. We think this treatment is useful as a new hepatic arterial infusion chemotherapy.

  • Research Products

    (19 results)

All 2014 2013 2012 2011

All Journal Article (9 results) (of which Peer Reviewed: 8 results) Presentation (9 results) (of which Invited: 1 results) Book (1 results)

  • [Journal Article] Serum transferrin as a predictor of prognosis for hepatic arterial infusion chemotherapy in advanced hepatocellular carcinoma2014

    • Author(s)
      Junichi Zaitsu, Takahiro Yamasaki, Issei Saeki, Yohei Harima, Takuya Iwamoto, Yumiko Harima, Toshihiko Matsumoto, Yohei Urata, Isao Hidaka, Tsuyoshi Ishikawa, Taro Takami, Naoki Yamamoto, Seiji Kaino, Koichi Uchida, Shuji Terai, Isao Sakaida
    • Journal Title

      Hepatol Res

      Volume: 44 Pages: 481-490

    • Peer Reviewed
  • [Journal Article] Association of tyrosine with insulin resistance in hepatitis C virus-related chronic liver disease2013

    • Author(s)
      Takashi Oono, Takahiro Yamasaki, Junichi Zaitsu, Issei Saeki, Takuya Iwamoto, Yumiko Harima, Yoshio Marumoto, Isao Hidaka, Yohei Urata, Tsuyoshi Ishikawa, Taro Takami, Makoto Segawa, Koichi Uchida, Shuji Terai, Ichiro Kunitugu, Tsuoshi Tanabe, Isao Sakaida
    • Journal Title

      Hepatol Res

      Volume: (Epu ahead of print)

    • Peer Reviewed
  • [Journal Article] Effect of transcatheter arterial infusion chemotherapy using iodized oil and degradable starch microspheres for hepatocellular carcinoma2012

    • Author(s)
      Takahiro Yamasaki, Issei Saeki, Yohei Harima, Junichi Zaitsu, Masaki Maeda, Haruko Tanimoto, Takuya Iwamoto, Isao Hidaka, Yohei Urata, Tsuyoshi Ishikawa, Taro Takami, Yuhki Yamaguchi, Koichi Uchida, Shuji Terai, Isao Sakaida
    • Journal Title

      J Gastroenterol

      Volume: 47 Pages: 715-722

    • Peer Reviewed
  • [Journal Article] Hepatic arterial infusion chemotherapy for advanced hepatocellular carcinoma and future treatments for the poor responders2012

    • Author(s)
      Takahiro Yamasaki, Isao Sakaida
    • Journal Title

      Hepatol Res

      Volume: 42 Pages: 340-348

    • Peer Reviewed
  • [Journal Article] Evaluation of a novel non-invasive (13) C-glucose breath test for the identification of diabetes mellitus in cirrhotic patients2012

    • Author(s)
      Masako Tsuchiya, Takahiro Yamasaki, Isao Sakaida
    • Journal Title

      Hepatol Res

      Volume: 42 Pages: 1196-1201

    • Peer Reviewed
  • [Journal Article] Hepatic arterial infusion chemotherapy in combination with pegylated interferonα-2b for advanced hepatocellular carcinoma2012

    • Author(s)
      Kohsuke Okita, Takahiro Yamasaki, Satoe Hamabe, Issei Saeki, Yohei Harima, Shuji Terai, Isao Sakaida
    • Journal Title

      Hepatogastroenterology

      Volume: 59 Pages: 533-537

    • Peer Reviewed
  • [Journal Article] Deferoxamine for advanced hepatocellular carcinoma2011

    • Author(s)
      Takahiro Yamasaki, Shuji Terai, Isao Sakaida
    • Journal Title

      N Engl J Med

      Volume: 365 Pages: 576-578

    • Peer Reviewed
  • [Journal Article] A novel transcatheter arterial infusion chemotherapy using iodized oil and degradable starch microspheres for hepatocellular carcinoma : a prospective randomized trial2011

    • Author(s)
      Takahiro Yamasaki, Satoe Hamabe, Issei Saeki, Yohei Harima, Yuhki Yamaguchi, Koichi Uchida, Shuji Terai, Isao Sakaida
    • Journal Title

      J Gastroenterol

      Volume: 46 Pages: 359-366

    • Peer Reviewed
  • [Journal Article] 肝細胞癌に対する新たな肝動脈カテーテル療法の有用性2011

    • Author(s)
      山﨑隆弘
    • Journal Title

      山口医学

      Volume: 60 Pages: 173-178

  • [Presentation] 肝癌治療に与える微小デンプン球の新規塞栓物質としての意義2014

    • Author(s)
      佐伯一成、山崎隆弘、日髙勲、他
    • Organizer
      第50回日本肝臓学会総会
    • Place of Presentation
      ホテルニューオータニ(東京)
    • Year and Date
      2014-05-29
  • [Presentation] Iron chelator therapy for advanced hepatocellular carcinoma 8^<th> international Symposium on Alcohlic Liver and Pancreatic Diseases and Cirrhosis2013

    • Author(s)
      Yamasaki Takahiro
    • Organizer
      ALPD2013
    • Place of Presentation
      The Ashok New Delhi (India)
    • Year and Date
      20131116-17
    • Invited
  • [Presentation] Association of tyrosine with insulin resistance in hepatitis C virus-related chronic liver disease2013

    • Author(s)
      Takahiro Yamasaki, Isao Hidaka, Koichi Uchida, et al
    • Organizer
      64^<th> Annual Liver Meeting in AASLD
    • Place of Presentation
      Washington Convention Center ( Washington DC, USA )
    • Year and Date
      20131101-05
  • [Presentation] Serum transferrin as apredictor of prognosis for hepatic arterial infusion chemotherapy in advanced hepatocellular carcinoma2013

    • Author(s)
      Takahiro Yamasaki, Isao Hidaka, Koichi Uchida, et al
    • Organizer
      The 23^<rd> Conference of APASL
    • Place of Presentation
      Suntec Singapore ( Singapore )
    • Year and Date
      20130606-09
  • [Presentation] Serum transferrin is an independent pre-treatment prognostic predictor for hepatic arterial infusion chemotherapy in advanced hepatocellular carcinoma2012

    • Author(s)
      Takahiro Yamasaki, Koichi Uchida, et al
    • Organizer
      6^<th> ILCA Annual Conference
    • Place of Presentation
      Inter Continental Berlin ( Berlin, Germany )
    • Year and Date
      20120914-16
  • [Presentation] Effect of a novel transcatheter arterial infusion chemotherapy for hepatocellular carcinoma2011

    • Author(s)
      Yamasaki Takahiro, Koichi Uchida, et al
    • Organizer
      5^<th> ILCA Annual Conference
    • Place of Presentation
      Convention and Exhibition Center ( Hong Kong, China )
    • Year and Date
      20110902-04
  • [Presentation] 肝細胞癌に対する新たな塞栓療法:リピオドール+微小デンプン球併用肝動注化学療法(Lipi+DSM-TAI)2011

    • Author(s)
      山﨑隆弘、内田耕一、他
    • Organizer
      第47回日本肝癌研究会
    • Place of Presentation
      静岡県コンベンションアーツセンター(静岡)
    • Year and Date
      2011-07-29
  • [Presentation] C型慢性肝疾患患者におけるインターフェロン少量長期投与の肝発癌抑制効果の検討2011

    • Author(s)
      日髙勲、山﨑隆弘、坂井田功
    • Organizer
      第47回日本肝癌研究会
    • Place of Presentation
      静岡県コンベンションアーツセンター(静岡)
    • Year and Date
      2011-07-28
  • [Presentation] 肝細胞癌に対するリピオドール+微小デンプン球併用化学療法(Lipi+DSM-TAI):奏功に寄与する因子の検討2011

    • Author(s)
      山﨑隆弘、浦田洋平、坂井田功
    • Organizer
      第47回日本肝臓学会総会
    • Place of Presentation
      ホテルグランパシフィックLE DAIBA(東京)
    • Year and Date
      2011-06-04
  • [Book] コンセンサス癌治療(最新の肝細胞癌の診断と治療)2013

    • Author(s)
      山﨑隆弘、他
    • Total Pages
      116(112-113)
    • Publisher
      へるす出版

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Published: 2015-07-16  

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