Development of the diagnosis and treatment of venous thromboembolism using animal model

2013 Fiscal Year Final Research Report

• Project/Area Number: 23591822
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Multi-year Fund
• Section: 一般
• Research Field: Radiation science
• Research Institution: University of Miyazaki
• Principal Investigator: TAMURA Shozo 宮崎大学, 医学部, 教授 (60150439)
• Co-Investigator(Kenkyū-buntansha): YANO Takanori 宮崎大学, 医学部, 講師 (20315378) ; HATAKEYAMA Kinta 宮崎大学, 医学部, 准教授 (60325735) ; YAMASHITA Atsushi 宮崎大学, 医学部, 助教 (90372797)
• Project Period (FY): 2011 – 2013
• Keywords: 深部静脈血栓症 / 遺伝子導入 / ラット

Research Abstract

The purpose of this study is to examine the effects of the thrombolytic agents to various types of thrombosis in rat inferior vena cava (IVC). We exposed rat IVC and performed gene transfer using recombinant adenovirus. After gene transfer, venous thrombosis was induced by ligation of the IVC, and evaluated the antithrombotic effects of the thrombolytic agents. As a result, it was expected that we could evaluate the association between venous thrombosis and thrombolytic agents in this animal model.