2013 Fiscal Year Final Research Report

Synthesis of novel copper-labeled agents for PET imaging as an alternative to technetium radiopharmaceuticals

Research Project

Project/Area Number	23591829
Research Category	Grant-in-Aid for Scientific Research (C)
Allocation Type	Multi-year Fund
Section	一般
Research Field	Radiation science
Research Institution	Japan Atomic Energy Agency
Principal Investigator	SUGO Yumi 独立行政法人日本原子力研究開発機構, 原子力科学研究部門量子ビーム応用研究センター, 研究副主幹 (90354836)
Co-Investigator(Kenkyū-buntansha)	WATANABE Shigeki 独立行政法人日本原子力研究開発機構, 原子力科学研究部門量子ビーム応用研究センター, 研究員 (10450305)
Project Period (FY)	2011 – 2013
Keywords	放射性同位元素 / ポジトロン / Cu-64 / ペプチド
Research Abstract	Technetium-99m (Tc-99m) is most commonly used as diagnostic radiopharmaceuticals. Tc-99m is generated by decay of molybdenum-99 (Mo-99), of which supply depends fully on the import from foreign countries. Recently, the supply shortage is the serious problem in the hospital. Copper-64 (Cu-64) is a useful radionuclide in nuclear medicine, and can be produced by the cyclotron using (p,n) nuclear reaction from nickel-64 (Ni-64). In this study, we designed and synthesized some novel Cu-64 labeled agents for positron emission tomography (PET) imaging as an alternative to the Tc-99m radiopharmaceuticals.

(3 results)