Radical radiotherapy for elderly patients: establish the indication

2013 Fiscal Year Final Research Report

• Project/Area Number: 23591830
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Multi-year Fund
• Section: 一般
• Research Field: Radiation science
• Research Institution: Hokkaido University
• Principal Investigator: ONIMARU Rikiya 北海道大学, 医学(系)研究科(研究院), 准教授 (80374461)
• Project Period (FY): 2011 – 2013
• Keywords: 高齢者 / 体幹部定位放射線治療 / 肺癌 / 脊髄神経鞘腫

Research Abstract

We evaluated the clinical results of stereotactic body radiotherapy (SBRT) for patients with lung cancer aged 80 and over. Sixty-five patientswere evaluated. Overall survival (OS) was 47.4 % at 5 year. A patient with interstitial pneumonitis experienced Grade 3 radiation pneumonitis following lethal aspiration pneumonia.
We also evaluated the efficacy of 3-dimensional conformal fractionated radiotherapy for spinal schwannoma.One patient experienced transient expansion by 8 mm in diameter at 12 months after the completion of radiotherapy (35 mm to 43 mm), and then tumor size remained unchanged for 7 years. No severe late toxicity equal to or above Grade 3 was observed.
SBRT seems to be effective treatment for elderly patients, however, more research is needed to establish its indication.

Research Products

• [Journal Article] 放射線治療におけるPositron emission tomography (PET)検査の利用 (2011)
  • Author(s): 鬼丸力也、安田耕一、加藤徳雄、他
  • Journal Title: 頭頸部癌 Volume: 37(3) Pages: 376-380
• [Presentation] Stereotactic Body Radiation Therapy (SBRT) for Non-Small Cell Lung Cancer (2014)
  • Author(s): 鬼丸力也
  • Organizer: 第73回日本医学放射線学会総会
  • Place of Presentation: 横浜 (教育講演)
  • Year and Date: 2014-04-12
• [Presentation] Stereotactic Body Radiotherapy (SBRT) using Real-time Tracking Radiotherapy (RTRT) system for patients with lung cancer aged 80 and over (2012)
  • Author(s): Onimaru R, Katoh N, Inoue T, et al
  • Organizer: The 54^<th> Annual Meeting of American Society of Radiation Oncology (ASTRO)
  • Place of Presentation: Boston, USA
  • Year and Date: 20121028-31
• [Presentation] Efficacy of Stereotactic Body Radiotherapy (SBRT) for Patients with Lung Cancer Aged 75 and Over (2012)
  • Author(s): Onimaru R, Katoh N, Inoue T, Shimizu S, Tsuchiya K, Kinoshita R, Konishi-Sakakibara J, Onodera S, Yasuda K, Shirato H
  • Organizer: The 6th S.Takahashi Memorial Symposium & The 6th Japan-US Cancer Therapy International Joint Symposium
  • Place of Presentation: Hiroshima, Japan
  • Year and Date: 20120619-21
• [Presentation] Real-time tumor-tracking radiotherapy (RTRT) for non-small cell lung cancer (NSCLC) (2012)
  • Author(s): Onimaru R, Shimizu S, Kinoshita R, et al
  • Organizer: Second International Conference on Real-time Tumor-tracking Radiation Therapy with 4D Molecular Imaging Technique
  • Place of Presentation: Kyoto, Japan
  • Year and Date: 20120216-17
• [Presentation] 放射線治療におけるPETの利用北大の経験 (2012)
  • Author(s): 鬼丸力也、安田耕一、加藤徳雄、他
  • Organizer: 第24回日本高精度放射線外部照射研究会
  • Place of Presentation: 横浜
  • Year and Date: 2012-02-04
• [Presentation] 北海道大学病院での高齢者に対する放射線治療 (2011)
  • Author(s): 鬼丸力也
  • Organizer: 第56回北日本放射線腫瘍学研究会
  • Place of Presentation: 盛岡
  • Year and Date: 2011-06-16
• [Presentation] 放射線治療におけるPETの利用 (2011)
  • Author(s): 鬼丸力也、安田耕一、加藤徳雄、他
  • Organizer: 第35回日本頭頸部癌学会
  • Place of Presentation: 名古屋
  • Year and Date: 2011-06-10