2013 Fiscal Year Final Research Report
Fundamental study for development of a new preventive method of radiation pneumonitis
| Project/Area Number |
23591835
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Radiation science
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| Research Institution | The University of Tokyo |
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Principal Investigator |
IGAKI Hiroshi 東京大学, 医学部附属病院, 講師 (90361344)
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| Project Period (FY) |
2011 – 2013
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| Keywords | 放射線肺臓炎 / スピロノラクトン / レニン‐アンギオテンシン‐アルドステロン系 |
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| Research Abstract |
The purpose of this study was to reveal the anti-fibrotic effect of spironolactone after pulmonary irradiation by an experimental system of rats. Female Wistar rats underwent local irradiation of the right whole thorax with a single dose of 15Gy by 200kVp x-rays. 90-day release pellets of 200mg of spironolactone were implanted in the rat's left back subcutaneously before or after irradiation. 13 weeks after irradiation, rats were sacrificed and bilateral lungs were removed and fixed in buffered formaldehyde for histopathological examinations. Fibrotic changes and foamy macrophage infiltrations were evaluated for each lung. The fibrotic changes of the irradiated lungs were severer when spironolactone was administered before irradiation. If spironolactone administration was delayed after irradiation, fibrotic change was not suppressed by spironolactone. Foamy macrophage infiltrations were not significantly different among the groups of different timings of spironolactone administration.
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Research Products
(20 results)
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[Journal Article] Corticospinal tract-sparing intensity-modulated radiotherapy treatment planning2014
Author(s)
Igaki H, Sakumi A, Mukasa A, Saito K, Kunimatsu A, Masutani Y, Hanakita S, Ino K, Haga A, Nakagawa K, Ohtomo K
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Journal Title
Rep Pract Oncol Radiother
Volume: (in press)
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[Journal Article] Dose verification of volumetric modulated arc therapy (VMAT) by use of in-treatment linac parameters2013
Author(s)
Haga A, Sakumi A, Okano Y, Itoh S, Saotome N, Kida S, Igaki H, Shiraishi K, Yamashita H, Ohtomo K, Nakagawa K
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Journal Title
Radiol Phys Technol
Volume: 6(2)
Pages: 335-342
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