• Search Research Projects
  • Search Researchers
  • How to Use
  1. Back to project page

2013 Fiscal Year Annual Research Report

腫瘍免疫に基づくアブスコパル効果の解明と画期的な放射線治療戦略の開発

Research Project

Project/Area Number 23591837
Research InstitutionThe University of Tokyo

Principal Investigator

白石 憲史郎  東京大学, 医学部附属病院, 助教 (40447404)

Co-Investigator(Kenkyū-buntansha) 新部 譲  北里大学, 医学部, 講師 (00372912)
Keywords腫瘍免疫 / アブスコパル / 放射線治療
Research Abstract

①放射線治療と腫瘍免疫併用における基礎的検討
放射線照射と免疫賦活剤併用により、免疫抑制性の環境を克服して抗腫瘍効果を誘導するために、担癌マウスモデルを用いた基礎的検討を行った。エフェクター候補としてCD4+、CD8+、NK/NKT細胞が同定された。
②再現性の高いabscopal effect誘導を利用した各種照射プロトコールの確立
雌性7週齢C57BL/6系あるいはMHC classの異なるBALB/c系マウスの右側部皮下にLewis lung carcinoma (3LL) あるいはColon26細胞を(primary tumor)、左側腹部皮下に3LLあるいはColon26/MethAを(secondary tumor)移植後、右側腹部の腫瘍のみに6Gy(6MeV電子線)照射しケモカインECI301を静脈内投与すると種々の組合せで有意なabscopal effectが観察された。共同研究者の新部は、特に肺癌・乳癌においてabscopal effectを背景に説明が成り立つoligometastasis/oligo-recurrenceの実臨床症例を集積した。

  • Research Products

    (9 results)

All 2014 2013

All Journal Article (4 results) (of which Peer Reviewed: 4 results) Presentation (5 results)

  • [Journal Article] Salvage radiation therapy and chemoradiation therapy for postoperative locoregional recurrence of esophageal cancer.2014

    • Author(s)
      Kobayashi R, Yamashita H, Okuma K, Shiraishi K, Ohtomo K, Nakagawa K.
    • Journal Title

      Dis Esophagus

      Volume: 27 Pages: 72-8

    • DOI

      10.1111/dote.12068

    • Peer Reviewed
  • [Journal Article] Independent absorbed-dose calculation using the Monte Carlo algorithm in volumetric modulated arc therapy.2014

    • Author(s)
      Haga A, Magome T, Takenaka S, Imae T, Sakumi A, Nomoto A, Igaki H, Shiraishi K, Yamashita H, Ohtomo K, Nakagawa K.
    • Journal Title

      Radiattion Oncology

      Volume: 9 Pages: in press

    • DOI

      10.1186/1748-717X-9-75

    • Peer Reviewed
  • [Journal Article] Correlation among 16 biological factors [p53, p21(waf1), MIB-1 (Ki-67), p16(INK4A), cyclin D1, E-cadherin, Bcl-2, TNF-α, NF-κB, TGF-β, MMP-7, COX-2, EGFR, HER2/neu, ER, and HIF-1α] and clinical outcomes following curative chemoradiation therapy in 10 patients with esophageal squamous cell carcinoma.2013

    • Author(s)
      Shibata-Kobayashi S, Yamashita H, Okuma K, Shiraishi K, Igaki H, Ohtomo K, Nakagawa K.
    • Journal Title

      Oncology Letters

      Volume: 5 Pages: 903-910

    • DOI

      10.1155/2012/454107

    • Peer Reviewed
  • [Journal Article] Dose verification of volumetric modulated arc therapy (VMAT) by use of in-treatment linac parameters.2013

    • Author(s)
      Haga A, Sakumi A, Okano Y, Itoh S, Saotome N, Kida S, Igaki H, Shiraishi K, Yamashita H, Ohtomo K, Nakagawa K.
    • Journal Title

      Radiol Phys Technol

      Volume: 6 Pages: 335-42

    • DOI

      10.1007/s12194-013-0205-6

    • Peer Reviewed
  • [Presentation] 乳房温存療法後の二次発癌は独立した予後不良因子である.2013

    • Author(s)
      白石憲史郎, 中川恵一, 河守次郎, 衣袋健司, 福内 敦, 西 常博.
    • Organizer
      日本放射線腫瘍学会第26回学術大会
    • Place of Presentation
      青森
    • Year and Date
      20131018-20131020
  • [Presentation] Impact of Intensive Local Control with Radiation Volumetric Modulated Arc Therapy (VMAT) in the Treatment of Localized Prostate Cancer: Initial Experience in 200 Patients.2013

    • Author(s)
      Shiraishi K, Yamamoto K, Haga A, Sakumi A, Futaguchi M, Nomoto A, Onoe T, Nakagawa K.
    • Organizer
      The American Society for Therapeutic Radiology and Oncology 55th Annual Meeting
    • Place of Presentation
      Atlanta, USA
    • Year and Date
      20130921-20130924
  • [Presentation] Secondary cancers after breast-conserving therapy in Tokyo database.2013

    • Author(s)
      Shiraishi K, Nakagawa K, Kawamori J, Ibukuro K, Fukuuchi A, Nishi T, Shinozaki T.
    • Organizer
      The Breast Cancer Symposium
    • Place of Presentation
      San Francisco, USA
    • Year and Date
      20130907-20130909
  • [Presentation] 乳房温存療法における照射範囲外の低線量評価と二次発癌.2013

    • Author(s)
      白石憲史郎, 中川恵一, 河守次郎, 衣袋健司, 福内 敦, 西 常博, 白木 尚, 作美 明, 篠崎智大.
    • Organizer
      第21回日本乳癌学会学術総会
    • Place of Presentation
      静岡
    • Year and Date
      20130627-20130629
  • [Presentation] Scattering contributions in out-of-field dosimetry using Monte Carlo calculation for breast conserving therapy.2013

    • Author(s)
      Shiraishi K, Sakumi A, Shiraki T, Haga A, Yoda K.
    • Organizer
      The 2nd ESTRO (European Society for Therapeutic Radiology and Oncology Anniversary) Forum.
    • Place of Presentation
      Geneva, Switzerland
    • Year and Date
      20130419-20130423

URL: 

Published: 2015-05-28  

Information User Guide FAQ News Terms of Use Attribution of KAKENHI

Powered by NII kakenhi